This article shows that mice treated with vitamin C (ascorbate) have a complicated response to the treatment: low doses produce more stereotyped behavior; and higher doses produce less.
Dopamine agonists, or compounds that act like dopamine in the brain (for example, amphetamines), produce repetitive, stereotyped behavior in humans and other animals. This article showed that mice that were exposed to a dopamine agonist had less stereotyped behavior if they had been treated with vitamin C at a relatively high dose, and more stereotyped behavior when they were treated with a lower dose of vitamin C. Also, vitamin C at the higher dose made several psychiatric drugs, including haloperidol, more effective in treating these stereotyped behaviors. The authors conclude that vitamin C at higher doses reduces the activity of the dopamine system.
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