This article gives an overview of the biochemistry of vitamin B6, highlighting the importance of this nutrient to human health.
The author first explains that vitamin B6 (pyridoxine) is converted into the active form (PLP) in the liver. PLP is then involved in over 60 naturally-occurring chemical reactions in the body and brain, including the creation of several important neurotransmitters. The author points out that in children, B6 intake is often too low. B6 deficiency can result in depression, moodiness, sleeplessness, and lack of motivation. The author outlines the evidence for the use of B6 supplementation in several disorders, including autism, heart disease, depression, immune disorders, and premenstrual syndrome. Finally, the author concludes with a discussion of the side effects of extremely high doses of B6 (2-6 grams per day), which include numbness and difficulty walking.
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