Research: Risperidone-Induced Prolactin Elevation in a Prospective Study of Children, Adolescents, and Adults with Mental Retardation and Pervasive Developmental Disorders

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Authored by Hellings, JA, Zarcone JR, Valdovinos MG, Reese RM, Gaughan E., and Schroeder SR in Journal of Child and Adolescent Psychopharmacology, Volume 15, Issue 6, p. 885-892, (2005).

Article summary (posted Mar 28, 2007):

Risperidone therapy may have a bad effect on puberty and bone health.

Prolactin is a hormone that affects puberty, bone health, blood sugar control, and ability to breastfeed. This paper looked at blood prolactin levels in a small group of a large prospective crossover study of people with pervasive developmental disorder (PDD) who were given risperidone as a treatment for behavioral problems. The study looked at children, adolescents, and adults who had been on risperidone for 6 months. Children, adolescents, and adults on risperidone all had very high levels of prolactin. The authors note that the study only had 10 children and is therefore small.

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adults with autism, control, hormones, pervasive developmental disorder (PDD), prospective study, Risperdal (risperidone), therapy, treatment
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