Autism Therapy: antagonist

definition of antagonist: Chemical that binds to a receptor and lowers or inhibits the normal receptor activity. For example, a dopamine receptor antagonist inhibits the normal functions of the dopamine receptor.

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Neuropsychopharmacology, by Bear, MF, Dolen G., Osterwell E., and Nagarajan N., published in 2007, summarized Jan 14, 2008

A new class of drug (mGluR5 antagonist) may help the brains of people with autism to work better.

This review article describes Fragile X Syndrome and relates therapies for Fragile X Syndrome to therapies for autism. Both Fragile X Syndrome and autism result from brain problems involving the connection between different parts of the brain. The authors believe that this can be caused by too much protein in the brain. They believe that mGluR5 antagonists may help by decreasing the amount of protein in the brain of people with autism. This drug has not yet been tested in people.


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