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Healing Thresholds Autism Therapy Topic Feed http://autism.healingthresholds.com/therapy/anti-oxidant/feed en Novel Therapeutic Targets for Autism http://autism.healingthresholds.com/research/novel-therapeutic-targets-autism <div id="biblio-node"><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.atitle=Novel+Therapeutic+Targets+for+Autism&rft.title=Trends+in+Pharmacological+Sciences&rft.date=2008&rft.volume=29&rft.issue=8&rft.spage=375&rft.epage=382&rft.aulast=Theoharides&rft.aufirst=TC"></span><table> <tbody> <tr class="odd"><td class="biblio-row-title biblio-field-title-title">Title</td><td class="biblio-field-contents-title">Novel Therapeutic Targets for Autism</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-type">Publication Type</td><td class="biblio-field-contents-type">Journal Article</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-authors">Authors</td><td class="biblio-field-contents-authors"><a href="/research-index/author/1641">Theoharides TC</a>, <a href="/research-index/author/1642">Doyle R</a>, <a href="/research-index/author/1643">Francis K</a>, <a href="/research-index/author/1644">Conti P</a>, <a href="/research-index/author/1645">Kalogeromitros D</a></td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-secondary-title">Journal Title</td><td class="biblio-field-contents-secondary-title">Trends in Pharmacological Sciences</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-year">Year of Publication</td><td class="biblio-field-contents-year">2008</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-volume">Volume</td><td class="biblio-field-contents-volume">29</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-issue">Issue</td><td class="biblio-field-contents-issue">8</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-pages">Pages</td><td class="biblio-field-contents-pages">375-382</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-url">URL for Abstract</td><td class="biblio-field-contents-url"><a href="http://www.ncbi.nlm.nih.gov/pubmed/18606459?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">http://www.ncbi.nlm.nih.gov/pubmed/18606459?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum</a></td> </tr> <tr class="even"><td valign="top">Full Text</td><td> <p>Some <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drugs</cite></a> that stop the allergic response of the <a class="glossary-term" href="/therapy/immune-system"><cite title=" System in the body that normally fights infections and other diseases such as cancer.">immune system</cite></a> may be able to help with the symptoms of <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>.</p> <p>This article presents the authors' view that <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> is caused by problems in the <a class="glossary-term" href="/therapy/immune-system"><cite title=" System in the body that normally fights infections and other diseases such as cancer.">immune</cite></a> cells of the <a class="glossary-term" href="/therapy/gastrointestinal"><cite title=" Parts of the body involved in eating and drinking, digestion, all the way through the making of waste products. Parts include throat, stomach, and intestines. Does not involve kidneys and parts included in the urinary tract.">gut</cite></a> and brain. The authors suggest that mast cells in the body release chemicals that affect <a class="glossary-term" href="/therapy/gastrointestinal"><cite title=" Parts of the body involved in eating and drinking, digestion, all the way through the making of waste products. Parts include throat, stomach, and intestines. Does not involve kidneys and parts included in the urinary tract.">gut</cite></a> and brain function. They further suggest that certain <a class="glossary-term" href="/therapy/supplements"><cite title=" Vitamins, minerals, amino acids, or fatty acids that can be purchased over-the-counter and taken to add specific nutrients to the diet. ">supplements</cite></a> (antioxidants) and <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drugs</cite></a> that block mast cells may be able to help people with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>. One such <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drug</cite></a> is cyproheptadine, which blocks histamine, which is released from mast cells, and blocks the brain chemical <a class="glossary-term" href="/therapy/serotonin"><cite title=" Chemical that is a neurotransmitter in the central nervous system. Serotonin is produced by certain types of neurons and by certain cells in the gastrointestinal tract. Serotonin is important in regulating mood, sleep, body temperature, appetite, and other processes in the body. ">serotonin</cite></a>. Cromolyn is another <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drug</cite></a> that seems to be able to stop mast cells and may help with some of the symptoms of <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>. The authors also propose the therapeutic use of SAMe (S-adenosylmethionine), which is an <a class="glossary-term" href="/therapy/anti-oxidant"><cite title=" Chemical that makes free radicals less damaging by stabilizing them. Many vitamins are anti-oxidants.">antioxidant</cite></a> <a class="glossary-term" href="/therapy/supplements"><cite title=" Vitamins, minerals, amino acids, or fatty acids that can be purchased over-the-counter and taken to add specific nutrients to the diet. ">supplement</cite></a>.</p> </td> </tr> </tbody> </table> </div> anti-oxidant autism drug immune system serotonin supplements Fri, 06 Mar 2009 15:57:27 +0000 scottie 2867 at http://autism.healingthresholds.com Biomarkers for Oxidative Stress: Clinical Application in Pediatric Medicine http://autism.healingthresholds.com/research/biomarkers-oxidative-stress-clinical-application-pediatric-medicine <div id="biblio-node"><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.atitle=Biomarkers+for+Oxidative+Stress%3A+Clinical+Application+in+Pediatric+Medicine&rft.title=Current+Medical+Chemistry&rft.date=2007&rft.volume=14&rft.issue=1&rft.spage=339&rft.epage=351&rft.aulast=Tsukahara&rft.auinit=H"></span><table> <tbody> <tr class="odd"><td class="biblio-row-title biblio-field-title-title">Title</td><td class="biblio-field-contents-title">Biomarkers for Oxidative Stress: Clinical Application in Pediatric Medicine</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-type">Publication Type</td><td class="biblio-field-contents-type">Journal Article</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-authors">Authors</td><td class="biblio-field-contents-authors"><a href="/research-index/author/718">Tsukahara H</a></td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-secondary-title">Journal Title</td><td class="biblio-field-contents-secondary-title">Current Medical Chemistry</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-year">Year of Publication</td><td class="biblio-field-contents-year">2007</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-volume">Volume</td><td class="biblio-field-contents-volume">14</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-issue">Issue</td><td class="biblio-field-contents-issue">1</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-pages">Pages</td><td class="biblio-field-contents-pages">339-351</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-url">URL for Abstract</td><td class="biblio-field-contents-url"><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17305536&query_hl=1&itool=pubmed_docsum">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17305536&query_hl=1&itool=pubmed_docsum</a></td> </tr> <tr class="even"><td valign="top">Full Text</td><td> <p>Some people use antioxidants to treat <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> even though there is not yet a lot of research in support of <a class="glossary-term" href="/therapy/anti-oxidant"><cite title=" Chemical that makes free radicals less damaging by stabilizing them. Many vitamins are anti-oxidants.">antioxidant</cite></a> <a class="glossary-term" href="/therapy/therapy"><cite title=" Intervention intended to help people with autism improve their health and behaviors. Therapy usually implies repeated sessions of treatments or activities. For example, speech therapy involves repeated visits with a trained therapist (or specialist) who works with the child to improve speech.">therapy</cite></a>.</p> <p>Antioxidants are things that prevent damage from happening in the body. <a class="glossary-term" href="/therapy/folate"><cite title=" Vitamin that is important for making and maintaining new cells. Folate is given as a supplement as an alternative therapy for autism. Folate helps the brain make neurotransmitters, and is very important for nervous system development. ">Folinic acid</cite></a>, betaine, and <a class="glossary-term" href="/therapy/vitamin-b12-cyanocobalamin"><cite title=" not yet defined.">methylcobalamin</cite></a> are antioxidants that have been used as a <a class="glossary-term" href="/therapy/therapy"><cite title=" Intervention intended to help people with autism improve their health and behaviors. Therapy usually implies repeated sessions of treatments or activities. For example, speech therapy involves repeated visits with a trained therapist (or specialist) who works with the child to improve speech.">therapy</cite></a> for <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>. This article reviewed the research behind using antioxidants to treat children. The author described the tests that are now available to see if damage is happening in the childâ??s body. <a class="glossary-term" href="/therapy/doctor"><cite title=" not yet defined.">Doctors</cite></a> still donâ??t know what sorts of things damage a childâ??s body such that he needs antioxidants.</p> </td> </tr> </tbody> </table> </div> anti-oxidant autism doctor folate oxidative stress pediatric stress therapy vitamin B12 (cyanocobalamin) Mon, 14 May 2007 18:32:27 +0000 scottie 1697 at http://autism.healingthresholds.com A Preliminary Trial of Ascorbic Acid as Supplemental Therapy for Autism http://autism.healingthresholds.com/research/preliminary-trial-ascorbic-acid-supplemental-therapy-autism <div id="biblio-node"><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.atitle=A+Preliminary+Trial+of+Ascorbic+Acid+as+Supplemental+Therapy+for+Autism&rft.title=Prog+Neuropsychopharmacol+Biol+Psychiatry.&rft.date=1993&rft.volume=17&rft.issue=5&rft.spage=765&rft.epage=774&rft.aulast=Dolske&rft.aufirst=MC"></span><table> <tbody> <tr class="odd"><td class="biblio-row-title biblio-field-title-title">Title</td><td class="biblio-field-contents-title">A Preliminary Trial of Ascorbic Acid as Supplemental Therapy for Autism</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-type">Publication Type</td><td class="biblio-field-contents-type">Journal Article</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-authors">Authors</td><td class="biblio-field-contents-authors"><a href="/research-index/author/158">Dolske MC</a>, <a href="/research-index/author/159">Spollen J</a>, <a href="/research-index/author/160">McKay S</a>, <a href="/research-index/author/161">Lancashire E</a>, <a href="/research-index/author/162">Tolbert L</a></td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-secondary-title">Journal Title</td><td class="biblio-field-contents-secondary-title">Prog Neuropsychopharmacol Biol Psychiatry.</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-year">Year of Publication</td><td class="biblio-field-contents-year">1993</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-volume">Volume</td><td class="biblio-field-contents-volume">17</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-issue">Issue</td><td class="biblio-field-contents-issue">5</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-pages">Pages</td><td class="biblio-field-contents-pages">765-774</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-url">URL for Abstract</td><td class="biblio-field-contents-url"><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8255984&query_hl=13&itool=pubmed_docsum">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8255984&query_hl=13&itool=pubmed_docsum</a></td> </tr> <tr class="even"><td valign="top">Full Text</td><td> <p>This article shows that <a class="glossary-term" href="/therapy/vitamin-c-ascorbic-acid"><cite title=" Vitamin C is an essential vitamin, which means it can only be obtained through the diet. It is found in many fruits and vegetables. ">vitamin C</cite></a> can improve behavior in children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>.</p> <p>In this well-<a class="glossary-term" href="/therapy/controlled-study"><cite title=" Experiment using good scientific methods, including double-blind procedures and placebo controls.">controlled study</cite></a>, the authors test the <a class="glossary-term" href="/therapy/individuals-disabilities-education-act-idea"><cite title=" not yet defined.">idea</cite></a> that <a class="glossary-term" href="/therapy/vitamin-c-ascorbic-acid"><cite title=" Vitamin C is an essential vitamin, which means it can only be obtained through the diet. It is found in many fruits and vegetables. ">vitamin C</cite></a> may be a useful <a class="glossary-term" href="/therapy/complementary-and-alternative-medicine-cam"><cite title=" Diverse medical and health care practices, therapies, and products that are not generally considered part of conventional main-stream medicine. Examples include acupuncture and herbal remedies.">alternative therapy</cite></a> for children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>. One group of 18 children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> (6 to 19 years old) was split into two <a class="glossary-term" href="/therapy/treatment"><cite title=" Something given to or performed on a person to improve health or behaviors. A treatment can include medical interventions such as giving medications. A treatment can also include non-medical interventions such as acupuncture. A treatment is usually considered something done in limited numbers. A series of treatments is often called therapy.">treatment</cite></a> groups with 9 children each. One group received <a class="glossary-term" href="/therapy/vitamin-c-ascorbic-acid"><cite title=" Vitamin C is an essential vitamin, which means it can only be obtained through the diet. It is found in many fruits and vegetables. ">vitamin C</cite></a> (8 g/70 kg/day or about 2 grams daily for a 40-pound child) for 20 weeks and <a class="glossary-term" href="/therapy/placebo"><cite title=" False drug, often consisting of a sugar pill with no active medicine, used for comparison with drugs being tested in a study. Usually the person taking the placebo is not told that they are only taking a sugar pill. ">placebo</cite></a> for 10 weeks, and the other group received the same dose of <a class="glossary-term" href="/therapy/vitamin-c-ascorbic-acid"><cite title=" Vitamin C is an essential vitamin, which means it can only be obtained through the diet. It is found in many fruits and vegetables. ">vitamin C</cite></a> for 10 weeks, <a class="glossary-term" href="/therapy/placebo"><cite title=" False drug, often consisting of a sugar pill with no active medicine, used for comparison with drugs being tested in a study. Usually the person taking the placebo is not told that they are only taking a sugar pill. ">placebo</cite></a> for 10 weeks, and <a class="glossary-term" href="/therapy/vitamin-c-ascorbic-acid"><cite title=" Vitamin C is an essential vitamin, which means it can only be obtained through the diet. It is found in many fruits and vegetables. ">vitamin C</cite></a> at the same dose for 10 more weeks. During each 10-week period, behaviors were scored by trained behavior raters who did not know what <a class="glossary-term" href="/therapy/treatment"><cite title=" Something given to or performed on a person to improve health or behaviors. A treatment can include medical interventions such as giving medications. A treatment can also include non-medical interventions such as acupuncture. A treatment is usually considered something done in limited numbers. A series of treatments is often called therapy.">treatment</cite></a> the children had received. Social, emotional, <a class="glossary-term" href="/therapy/sensory-integration"><cite title=" Neurological process that organizes sensation from one's own body and the environment. Sensory integration makes it possible to use the body effectively within the environment. Children with autism are believed to have difficulties integrating sensory information. One program, the Bolles Sensory Learning Program, uses stimulation of visual (visual integration training), auditory, and vestibular (balance) senses to help improve sensory issues.">sensory</cite></a>, and <a class="glossary-term" href="/therapy/language"><cite title=" not yet defined.">language</cite></a> behaviors were scored. The authors found a significant improvement in total behavior scores after <a class="glossary-term" href="/therapy/vitamin-c-ascorbic-acid"><cite title=" Vitamin C is an essential vitamin, which means it can only be obtained through the diet. It is found in many fruits and vegetables. ">vitamin C</cite></a> <a class="glossary-term" href="/therapy/treatment"><cite title=" Something given to or performed on a person to improve health or behaviors. A treatment can include medical interventions such as giving medications. A treatment can also include non-medical interventions such as acupuncture. A treatment is usually considered something done in limited numbers. A series of treatments is often called therapy.">treatment</cite></a> followed <a class="glossary-term" href="/therapy/placebo"><cite title=" False drug, often consisting of a sugar pill with no active medicine, used for comparison with drugs being tested in a study. Usually the person taking the placebo is not told that they are only taking a sugar pill. ">placebo</cite></a> <a class="glossary-term" href="/therapy/treatment"><cite title=" Something given to or performed on a person to improve health or behaviors. A treatment can include medical interventions such as giving medications. A treatment can also include non-medical interventions such as acupuncture. A treatment is usually considered something done in limited numbers. A series of treatments is often called therapy.">treatment</cite></a>, and a significant worsening of these scores after <a class="glossary-term" href="/therapy/vitamin-c-ascorbic-acid"><cite title=" Vitamin C is an essential vitamin, which means it can only be obtained through the diet. It is found in many fruits and vegetables. ">vitamin C</cite></a> <a class="glossary-term" href="/therapy/treatment"><cite title=" Something given to or performed on a person to improve health or behaviors. A treatment can include medical interventions such as giving medications. A treatment can also include non-medical interventions such as acupuncture. A treatment is usually considered something done in limited numbers. A series of treatments is often called therapy.">treatment</cite></a> was stopped and <a class="glossary-term" href="/therapy/placebo"><cite title=" False drug, often consisting of a sugar pill with no active medicine, used for comparison with drugs being tested in a study. Usually the person taking the placebo is not told that they are only taking a sugar pill. ">placebo</cite></a> was taken for 10 weeks.</p> </td> </tr> </tbody> </table> </div> anti-oxidant autism complementary and alternative medicine (CAM) controlled study Individuals with Disabilities Education Act (IDEA) language placebo psychiatry sensory integration supplements therapy treatment vitamin vitamin C (ascorbic acid) Sun, 22 Oct 2006 02:17:42 +0000 scottie 185 at http://autism.healingthresholds.com Altered Vascular Phenotype in Autism: Correlation with Oxidative Stress http://autism.healingthresholds.com/research/altered-vascular-phenotype-autism-correlation-oxidative-stress <div id="biblio-node"><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.atitle=Altered+Vascular+Phenotype+in+Autism%3A+Correlation+with+Oxidative+Stress&rft.title=Arch+Neurol.&rft.date=2006&rft.volume=63&rft.issue=8&rft.spage=1161&rft.epage=1164&rft.aulast=Yao&rft.auinit=Y"></span><table> <tbody> <tr class="odd"><td class="biblio-row-title biblio-field-title-title">Title</td><td class="biblio-field-contents-title">Altered Vascular Phenotype in Autism: Correlation with Oxidative Stress</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-type">Publication Type</td><td class="biblio-field-contents-type">Journal Article</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-authors">Authors</td><td class="biblio-field-contents-authors"><a href="/research-index/author/154">Yao Y</a>, <a href="/research-index/author/155">Walsh WJ</a>, <a href="/research-index/author/156">McGinnis WR</a>, <a href="/research-index/author/157">Pratico D</a></td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-secondary-title">Journal Title</td><td class="biblio-field-contents-secondary-title">Arch Neurol.</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-year">Year of Publication</td><td class="biblio-field-contents-year">2006</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-volume">Volume</td><td class="biblio-field-contents-volume">63</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-issue">Issue</td><td class="biblio-field-contents-issue">8</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-pages">Pages</td><td class="biblio-field-contents-pages">1161-1164</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-url">URL for Abstract</td><td class="biblio-field-contents-url"><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16908745&query_hl=1&itool=pubmed_docsum">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16908745&query_hl=1&itool=pubmed_docsum</a></td> </tr> <tr class="even"><td valign="top">Full Text</td><td> <p>This article suggests that <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> may be associated with <a class="glossary-term" href="/therapy/oxidative-stress"><cite title=" Condition in which free radicals cause damage to the body and brain. ">oxidative stress</cite></a> as well as changes in blood circulation.</p> <p>It is already known that children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> are likely to have more <a class="glossary-term" href="/therapy/oxidative-stress"><cite title=" Condition in which free radicals cause damage to the body and brain. ">oxidative stress</cite></a>, or difficulty in managing <a class="glossary-term" href="/therapy/free-radicals"><cite title=" Chemicals that can cause damage to living systems by changing the chemical structures of many of their biological compounds. ">free radicals</cite></a>, than children who do not have <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>. It is also known that children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> have unusual blood circulation. The authors of this study set out to determine if these facts could be biologically linked to one another. To do so, they tested the <a class="glossary-term" href="/therapy/urine"><cite title=" not yet defined.">urine</cite></a> of 26 children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> and 12 controls (ages not given) for biomarkers of <a class="glossary-term" href="/therapy/oxidative-stress"><cite title=" Condition in which free radicals cause damage to the body and brain. ">oxidative stress</cite></a> (<a class="glossary-term" href="/therapy/isoprostane"><cite title=" Biomarker for the damage of cell membranes by free radicals. Isoprostane is a chemical that is made when cell membranes are damaged. ">isoprostane</cite></a>) as well as two biomarkers for abnormal blood cells and blood flow. They found that the children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> had significantly higher levels of all three biomarkers than the controls. They also found a significant correlation between the level of <a class="glossary-term" href="/therapy/isoprostane"><cite title=" Biomarker for the damage of cell membranes by free radicals. Isoprostane is a chemical that is made when cell membranes are damaged. ">isoprostane</cite></a> and the levels of the two biomarkers for abnormal blood cells and blood flow, suggesting that there is a link between <a class="glossary-term" href="/therapy/oxidative-stress"><cite title=" Condition in which free radicals cause damage to the body and brain. ">oxidative stress</cite></a> and changes in blood circulation in children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>.</p> </td> </tr> </tbody> </table> </div> anti-oxidant autism free radicals isoprostane oxidative stress stress urine vitamin C (ascorbic acid) Sun, 22 Oct 2006 02:13:20 +0000 scottie 184 at http://autism.healingthresholds.com Increased Excretion of a Lipid Peroxidation Biomarker in Autism http://autism.healingthresholds.com/research/increased-excretion-lipid-peroxidation-biomarker-autism <div id="biblio-node"><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.atitle=Increased+Excretion+of+a+Lipid+Peroxidation+Biomarker+in+Autism&rft.title=Prostaglandins%2C+Leukotrienes+and+Essential+Fatty+Acids&rft.date=2005&rft.volume=73&rft.spage=379&rft.epage=384&rft.aulast=Ming&rft.auinit=X"></span><table> <tbody> <tr class="odd"><td class="biblio-row-title biblio-field-title-title">Title</td><td class="biblio-field-contents-title">Increased Excretion of a Lipid Peroxidation Biomarker in Autism</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-type">Publication Type</td><td class="biblio-field-contents-type">Journal Article</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-authors">Authors</td><td class="biblio-field-contents-authors"><a href="/research-index/author/148">Ming X</a>, <a href="/research-index/author/149">Stein TP</a>, <a href="/research-index/author/150">Brimacombe M</a>, <a href="/research-index/author/151">Johnson WG</a>, <a href="/research-index/author/152">Lambert GH</a>, <a href="/research-index/author/153">Wagner GC</a></td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-secondary-title">Journal Title</td><td class="biblio-field-contents-secondary-title">Prostaglandins, Leukotrienes and Essential Fatty Acids</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-year">Year of Publication</td><td class="biblio-field-contents-year">2005</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-volume">Volume</td><td class="biblio-field-contents-volume">73</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-pages">Pages</td><td class="biblio-field-contents-pages">379-384</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-url">URL for Abstract</td><td class="biblio-field-contents-url"><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=pubmed&term=ming+AND+stein+AND+oxidative&tool=fuzzy&ot=Ming+AND+Stein+AND+ixidative">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=pubmed&term=ming+AND+stein+AND+oxidative&tool=fuzzy&ot=Ming+AND+Stein+AND+ixidative</a></td> </tr> <tr class="odd"><td valign="top">Full Text</td><td> <p>This article suggests that <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> may be associated with <a class="glossary-term" href="/therapy/oxidative-stress"><cite title=" Condition in which free radicals cause damage to the body and brain. ">oxidative stress</cite></a> that results from difficulties in managing <a class="glossary-term" href="/therapy/free-radicals"><cite title=" Chemicals that can cause damage to living systems by changing the chemical structures of many of their biological compounds. ">free radicals</cite></a> in the body.</p> <p>The authors tested 33 children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> (ages not given) and 29 controls for biomarkers for <a class="glossary-term" href="/therapy/oxidative-stress"><cite title=" Condition in which free radicals cause damage to the body and brain. ">oxidative stress</cite></a>. They report that children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> had a <a class="glossary-term" href="/therapy/biomarker"><cite title=" Biological indicators or markers for a particular condition or state in the body. For example, if the biomarker for a disorder is present in an individual, that person is likely to have the disorder.">biomarker</cite></a> for <a class="glossary-term" href="/therapy/oxidative-stress"><cite title=" Condition in which free radicals cause damage to the body and brain. ">oxidative stress</cite></a> (<a class="glossary-term" href="/therapy/isoprostane"><cite title=" Biomarker for the damage of cell membranes by free radicals. Isoprostane is a chemical that is made when cell membranes are damaged. ">isoprostane</cite></a>) that was significantly higher than in controls. This <a class="glossary-term" href="/therapy/biomarker"><cite title=" Biological indicators or markers for a particular condition or state in the body. For example, if the biomarker for a disorder is present in an individual, that person is likely to have the disorder.">biomarker</cite></a> shows that cell membranes in the body and/or brain are likely to have been damaged by <a class="glossary-term" href="/therapy/free-radicals"><cite title=" Chemicals that can cause damage to living systems by changing the chemical structures of many of their biological compounds. ">free radicals</cite></a>. The authors conclude that children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> may be genetically more likely to develop <a class="glossary-term" href="/therapy/oxidative-stress"><cite title=" Condition in which free radicals cause damage to the body and brain. ">oxidative stress</cite></a>, supporting the use of anti-oxidants such as <a class="glossary-term" href="/therapy/vitamin-c-ascorbic-acid"><cite title=" Vitamin C is an essential vitamin, which means it can only be obtained through the diet. It is found in many fruits and vegetables. ">vitamin C</cite></a> in <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>.</p> </td> </tr> </tbody> </table> </div> anti-oxidant autism biomarker essential fatty acids (EFA) free radicals isoprostane oxidative stress stress vitamin vitamin C (ascorbic acid) Sun, 22 Oct 2006 02:09:27 +0000 scottie 183 at http://autism.healingthresholds.com