Autism Therapy: DHEA

definition of DHEA: not yet defined.

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Immune-Glutamatergic Dysfunction as a Central Mechanism of the Autism Spectrum Disorders
Current Medicinal Chemistry, by Blaylock, RL, and Strunecka A., published in 2009, summarized Mar 10, 2009

Vitamin B6, vitamin C, vitamin B12, magnesium, and omega-3 fatty acids may improve symptoms of autism.

Autism is a spectrum disease and research has shown that it is likely caused by many genes. This paper describes the idea that autism is caused by a problem with the glutamine chemical in the brain. The authors propose that if glutamine does not work well within the brain, then microglia cells in the brain may become active and secrete many factors that can harm the brain. These factors may then cause symptoms of autism in people who are at genetic risk for autism. Treatment approaches would include use of supplements and reduction of processed foods that have additives that contain glutamate and aspartate.

SPECIAL SUPPLEMENTS AND COMPOUNDS, WHICH ARE KNOWN TO REDUCE EXCITOTOXICITY:
Methylcobalamin (vitamin B12)
Pyridoxal-5 phosphate (vitamin B6)
Vitamin E (mixed tocopherols)
Vitamin C (buffered)
CoQ10
Acetyl-L-carnitine
Alpha-lipoic acid
Magnesium glycinate or lactate
Zinc
Flavonoids

SPECIAL SUPPLEMENTS AND COMPOUNDS, WHICH ARE KNOWN TO REDUCE MICROGLIAL ACTIVATION:
Ibupropen
Mincycline
Ferulic acid
DHEA
Curcumin
Quercetin
Silymarin
Baicalein
Resveratrol
DHA/EPA


A Prospective Assessment of Androgen Levels in Patients with Autistic Spectrum Disorders: Biochemical Underpinnings and Suggested Therapies
Neuroendocrinology Letters, by Geier, DA, and Geier MR, published in 2007, summarized Mar 4, 2008

Therapies that lower levels of male hormones may help symptoms of autism.

Autism is more common in boys than girls. This study looked at levels of the hormone androgen in 70 patients with autism. The authors found that patients had higher levels of androgen and androgen-like hormones than reported normal values. They found higher levels of serum testosterone (158% of normal), serum free testosterone (214% of normal), percent free testosterone (121% of normal), DHEA (192% of normal), and androstenedione (173% of normal). Both males and females had higher than normal levels of testosterone.


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