Research summaries for autism therapy: drug

definition of drug: Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications.

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Many drugs are prescribed to help manage the symptoms of autism and yet very few studies have been done to demonstrate that these medications are helpful.

This article describes the use of drug therapy in the U.S. for youth with autism. Recently, there has been a large increase in the use of brain drugs (psychotropic medications) to treat young people with autism. This may be due to the fact that more people know about autism. It may also be due to the presence of new drugs such as atypical antipsychotics and newer stimulants. There are no guidelines to help doctors know how to prescribe brain drugs to help children with autism.

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Omega-3 fatty acid supplements may reduce the incidence of sudden cardiac death in patients with autism who are prescribed atypical antipsychotics.

This paper describes the logic behind using omega-3 fatty acids to protect the hearts of children given brain drugs (atypical antipsychotics). Atypical antipsychotics may cause sudden death by causing the heart to stop beating. Omega-3 fatty acids have been shown to protect people from heart disease. The authors note that, in many cases, children with autism have only low levels of omega-3 fatty acids in their blood. They believe that omega-3 fatty acid supplements may help children with autism in many ways and may help to protect the heart of children giving atypical antipsychotics.

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Aripiprazole may help to treat irritability in children with autism.

This double-blind, placebo-controlled study compared the atypical antipsychotic aripiprazole with placebo in terms of being able to reduce irritability in children (aged 6 to 17 years) with autism. This eight week study found that aripiprazole was able to reduce irritability in children with autism. Children who received aripiprazole also had decreased hyperactivity. There was a high placebo response rate of 35% on this study. The authors also note that this was a fixed-dose study and therefore doctors were not able to change the dose of the drug based upon the patient’s response to the drug.

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There is no good evidence to support the use of pharmacological treatments or supplements in people with Fragile X Syndrome in general or those with a diagnosis of Fragile X Syndrome and autism.

This article reviews the research on drug therapy for the treatment of symptoms of Fragile X Syndrome. Most of the studies that they reviewed were very small and therefore it was hard for the studies to see an effect from the drug if such an effect did exist. Most of the studies were also poorly designed. The authors noted that a poorly designed folic acid study showed promise that folic acid supplements (10 mg/day) may raise the IQ of young children with Fragile X syndrome. Read more...


Synonyms for drug include: drug therapies, drug therapy, drugs
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