Autism Therapy: evidence-based medicine (EBM)

definition of evidence-based medicine (EBM): Medical decisions that are based entirely upon data from well-controlled and well-designed scientific studies. The more positive studies available, the stronger the evidence behind the medicine. Consequently, a few case studies are not considered to be enough scientific evidence to support a therapeutic practice as evidence-based.

Evidence-Based Medicine (EBM) Overview

Published Oct 19, 2009, last updated Nov 30, 2009

There are many different therapies that are regularly proposed as effective in treating autism. Some of these have been proven effective in a research setting and some have not. A therapy does not have to be proven effective in order to be effective. Sometimes many years must pass and many different experiments and studies have to be performed before enough evidence has accumulated to indicate that a given therapy is effective for treating autism. Scientists and doctors are constantly striving to find safe and effective ways to treat autism, however. So, if years have passed since a therapy has been tried and no peer-reviewed research has been published supporting the effectiveness of the therapy, then there is reason to doubt the therapy is effective.

Many physicians and health insurance providers are reluctant to recommend therapies that have not been proven effective by scientific study. This is because they are reluctant to waste time and money on a therapeutic approach that they are not certain will work. Instead, they rely upon effective therapies that have met rigorous standards as demonstrated by well thought out experiments.

Annals of Clinical Psychiatry, by Granpeesheh, D., Tarbox J., and Dixon DR, published in 2009, summarized Jun 10, 2010

It may help children with autism if psychiatrists learn about applied behavior analysis (ABA) therapy and learn how to work with ABA therapists.

Most autism therapies have not been studied using evidence-based scientific research. This article reviews ABA therapy for children with autism and the research that supports its use. The article also describes how ABA can be used with psychiatry. The authors note that the most gains are found when ABA is used 30 to 40 hours per week as per the early intensive behavioral intervention model. The early intensive behavioral intervention model is also known for working on all areas of functioning where the child has problems.


BMC Neurology, by Rueda, J. - R., Ballesteros J., and Tejada M. - I., published in 2009, summarized Apr 29, 2010

There is no good evidence to support the use of pharmacological treatments or supplements in people with Fragile X Syndrome in general or those with a diagnosis of Fragile X Syndrome and autism.

This article reviews the research on drug therapy for the treatment of symptoms of Fragile X Syndrome. Most of the studies that they reviewed were very small and therefore it was hard for the studies to see an effect from the drug if such an effect did exist. Most of the studies were also poorly designed. The authors noted that a poorly designed folic acid study showed promise that folic acid supplements (10 mg/day) may raise the IQ of young children with Fragile X syndrome. One small study showed found methylphenidate to be helpful for children with Fragile X syndrome, but the study was short and poorly designed.


J Autism Dev Disorder, by Bent, S., Bertoglio K., and Hendren RL, published in 2009, summarized Apr 6, 2010

There is currently not enough scientific evidence to determine if omega-3 fatty acids are safe and effective as a treatment for autism.

Omega-3 fatty acids are often used as a treatment for autism. This article reviews all published studies on the treatment effects of omega-3 fatty acids in children with autism. While there are no concrete studies that show that omega-3 fatty acids help with autism, the supplement appears to be safe. The studies that have been done so far raise hope that omega -3 fatty acids may help with autism and these studies should be followed with more research. The authors suggest that patients discuss the use of omega-3 fatty acids with their doctors before starting to use them.


Focus on Exceptional Children, by Simpson, RL, published in 2008, summarized Feb 15, 2010

Individualized programs based on the needs of the child and family may help the successful education of children with autism.

This article describes the best use of programs designed to teach children with autism. The authors talked about how the most effective programs may be geared to the needs of the child. Choosing the type of therapy and intervention may best consider possible effectiveness of the therapy based on current research evidence. Different options might work better for different children, families, schools, and communities. The authors also said that measuring progress is an important part of a successful plan.


The Miller College Institute is offering a seminar to teachers on evidence-based teaching methods for children with autism. This Michigan college seminar doesn’t focus on a single method of teaching, but on an understanding of autism. Educators are then asked to use their own teaching skills to work with the kids. The participants are also encouraged to exchange ideas with one another. Another focus is on helping children communicate and learn using more visual methods. The course is geared towards general education teachers who work with developmentally delayed children, but is open to anyone involved with autism.

Read original article: New Miller College Seminar Aids in Autism Battle


Paul O’Donoghue, an Irish clinical psychologist, has written an article highlighting a study on use of cognitive behavior therapy (CBT) for kids with autism and other developmental delays. O’Donoghue first explains the difference between evidence-based therapy and alternative therapies. He then goes on to discuss a study using a computer game to teach evidence-based CBT to children who “otherwise find the usual therapeutic process boring or difficult.” Dr Gary O’Reilly of the School of Psychology at UCD led a team to develop a game that would provide feedback to behaviors in an attempt to increase positive behaviors and decrease negative ones. The game allows the children to visit a place called Gnattenborough’s Island where they are introduced to the main character, David Gnattenborough, who acts as a guide. The kids learn to recognize and deal with different emotions, for example, NATS (Negative Automatic Thoughts). The training is generic, but children keep a personalized diary on their progress. A CBT-trained therapist leads the game.


Strive Community is New Jersey’s answer to what one mom calls “a tsunami” of children with autism who will reach adulthood in the next few years. Strive provides an adult day program that uses evidence-based, best practice therapies for autism. They are utilizing applied behavior analysis (ABA) techniques from the Princeton Child Development Institute, who offers both a day program and group homes. Strive was founded by parents who are using their personnel expertise to bring the center as well as a bookstore to fruition. [words] Maplewood’s Bookstore provides an inclusive and intellectual environment for adults with autism.

Read original article: Locals Prepare for "Tsunami" of Adults with Autism


The Millers, parents of a son with autism, could not find any therapy that worked for their son until they discovered The Brain Center. Founded by Dr. Vicki Parker, The Brain Center works with children and adults to improve areas of the brain including speech, focus, memory, attention span, auditory, and visual processing. Parker has over 25 years experience as a speech pathologist with a focus on neurological disorders. Each child is assessed and an individual program formed. The Miller’s son works on his cognitive learning skills: “tangrams - shape-based puzzles - playing matching games, learning to track something with his eyes and how to focus on tasks and instructions.” Even though their son continues with special education classes, The Brain Trainer integrates a more individualized treatment plan for him.

Read original article: Center Helps Your Brain Work Better



Please comment on this autism topic.

ABA is good for teaching discrete skills to kids with autism. Actually, there are conflicting analyses of the ABA effectiveness literature....and generalization is still a major challenge. ANd, with ABA, a teacher can focus entirely on nonfunctional skills in isolation with ABA.

 

THere is now growing evidence of the usefulness of developmental interventions for kids on the spectrum, such as DIR. I think a combination of therapies, as DIR and ABA can help a child learn to read, for example, and also to relate and connect with other people.


Responding to Social Thinking

Dec 17, 2010 by Anonymous

Social Thinking by WInner is a nice concept and great for therapists who need a recipe for treating social communication skills. However, much more research must be conducted in order to determine the true benefit of this curriculum, as well as to demonstrate that it is in fact evidence-based. Further, research should be conducted by outside parties---not just those who have developed the program.


Responding to Social Thinking

Dec 17, 2010 by Anonymous

Social Thinking by WInner is a nice concept and great for therapists who need a recipe for treating social communication skills. However, much more research must be conducted in order to determine the true benefit of this curriculum, as well as to demonstrate that it is in fact evidence-based. Further, research should be conducted by outside parties---not just those who have developed the program.


 

Can nutrition help verbal skills in children with autism? A study reported the August 2009 issue of Alternative Therapies says yes, for some children. Combined vitamin E and omega 3 therapy may help a type of verbal apraxia (a type of speech problem) that may be linked to food allergies and nutritional problems.

 Children with verbal apraxia have trouble pronouncing words and may have severe speech problems. Many scientists have thought that verbal apraxia is a brain disorder. This study suggests that verbal apraxia may also be related to metabolism differences and nutritional problems.

 Metabolism is the process of making energy from food. Metabolism is a complex system of enzymes, proteins, fats, and carbohydrates that work together to digest food and turn it into energy that the body can use. People likely have a wide range of metabolic differences. Some of those differences can be quite large for some individuals. In this study, they suggest that some children with autism may have metabolism differences that affect how they process foods, and how their brain works.

 What did the study show? This study tested 187 children with verbal apraxia, and many of them also had autism. All of the children took 400-3,000 International Units of vitamin E daily. They also took 1-3 grams of polyunsaturated fats (including omega 3 fatty acids) per day.

 Almost all of the families (97%) reported improvements in speech, imitation, coordination, eye contact, and other skills with vitamin E and omega-3 therapy. There were few side effects reported during the length of the study.

 The authors also described blood test results for nutritional information about 26 of the children. They reported low carnitine levels, high anti-gluten antibodies (suggesting a gluten allergy), low vitamin D levels, and fat absorption problems in most of the children they tested. They described how nutrition and metabolism might be different in some children with autism.

 What do these results mean for children with verbal apraxia and autism? The results are exciting because 97% of the children showed improvements, and there were few side effects. Sounds perfect, doesn’t it? But it’s not quite as perfect as it sounds.

 There are some major limitations of this study. First of all, the researchers asked parents to give their subjective opinion of improvements. The parents knew they were in a study. Although they were given specific improvements to look for, there is a possibility of bias in favor of reporting a good result.

 Secondly, they did not use placebo controls. All of the parents and children knew they were getting the supplements. There is the possibility of the “placebo effect” which is when people taking placebo (“sugar pills”) report feeling better or actually show improvements. Many think it is the power of the mind/body connection that somehow influences how they feel or even how their body physically responds. There is scientific evidence for brain connections to the immune and endocrine systems to support these observations. It is possible that, in this study, the children and/or parents were hopeful that the supplements would work, and that influenced the outcome. There was a placebo effect observed in a recent study of citalopram and autism in children.

 Third, the supplements may be helpful for only a subset of children with verbal apraxia. The researchers chose children with verbal apraxia who also had metabolism differences….

 What is the bottom line for omega-3 and vitamin E from this study? In spite of the shortcomings of this study, the results are very promising. Children with verbal apraxia may benefit from vitamin E and omega-3 supplements, which may get their metabolism on a better track. And researchers will continue to explore the nutrition/metabolism link with brain function. Good nutrition is likely to be important for many brain functions, not just verbal apraxia.



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  • Synonyms for evidence-based medicine (EBM) include: evidence, evidence-based, evidence-based teaching, evidence-based therapy, well designed studies, well designed study, well-designed studies, well-designed study
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