Research summaries for autism therapy: glutathione (L-glutathione)

definition of glutathione (L-glutathione): A small peptide that is found naturally in the body and is important in many bodily functions. It is an antioxidant (protects cells and tissues from damage) and also plays a role in clearing toxins from the body.
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Efficacy of Methylcobalamin and Folinic Acid Treatment on Glutathione Redox Status in Children with Autism, Summarized Aug 17, 2010

Vitamin B12 and folic acid may help to normalize the metabolism of children with autism.

Around 74% of parents use complementary and alternative medicine (CAM) to treat their children with autism. The goal of this study was to show whether or not vitamin B12 and folic acid could improve markers in the blood of children with autism. The authors measured SAM:SAH and GSH:GSSG in the blood of 40 children aged 2 to 7 years who had autism. The children were given 75 µg/kg of vitamin B12 (methylcobalamin) 2 times/week and 400 µg folinic acid 2 times/day for 3 months. The vitamins improved the blood results in the children, but did not bring the blood results to normal levels.

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Safety and Efficacy of Oral DMSA Therapy for Children with Autism Spectrum Disorders: Part A – Medical Results, Summarized Mar 4, 2010

Oral dimercapto succinic acid (DMSA) therapy may be helpful in normalizing red blood cell glutathione levels in children with autism.

This study was designed to see if DMSA therapy (9 doses over 3 days, 10 mg/kg-dose) would cause children with autism to excrete toxic metals. DMSA was very good at causing lead to be released from the body. The children seemed to have less lead in their bodies after treatment than children in other research studies. Children were given 3 rounds of DMSA treatment. Researchers said that 80% of the children may need more than three rounds of DMSA treatment in order to remove all of the toxic metals. The authors said that DMSA therapy may reduce toxic metals and improve glutathione levels with few apparent side effects.

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Efficacy of Methylcobalamin and Folinic Acid Treatment on Glutathione Redox Status in Children with Autism, Summarized Sep 14, 2009

Treatment with metabolic supplements such as vitamins B12 and folic acid may help children with autism.

About 74% or parents use complementary and alternative medicine (CAM) to treat their children with autism. This study looked to see whether three months of treatment with vitamin B12 (75 mcg/kg methylcobalamin 2 times/week) and folic acid (400 mcg folinic acid 2 times/day) might help children with autism. The authors did not look at symptoms of autism, but only looked at changes in compounds in the blood of children with autism. The treatment increased blood levels of cysteine and GSH and reduced levels of GSSG. While the levels of these compounds became more like the levels seen in children who do not have autism, the levels did not become normal with treatment.

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Synonyms for glutathione (L-glutathione) include: glutathione, L-glutathione, Reduced L-glutathione
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