This article reports that certain types of epilepsy can be controlled with vitamin B6 supplementation, and may be even better controlled with PLP supplementation.
It is known that vitamin B6 can help reduce the seizures of children with epilepsy. The authors of this article wanted to determine whether supplementation with PLP, the active form of vitamin B6, would work even better than supplementation with vitamin B6. This study focused on 94 children with severe idiopathic epilepsy (8 months to 15 years old). These children received PLP intravenously. In eleven patients, seizures stopped after PLP treatment, and in these patients, vitamin B6 supplements (50 mg/kg body weight per day, or about 909 mg for a 40-pound child) were used instead of intravenous PLP. After the switch to vitamin B6, six of the eleven patients were still free of seizures. No significant side effects were observed. The authors note that it is not yet known why some children with epilepsy respond to vitamin B6 or PLP treatment.
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Biomedical Treatments
Oct 25, 2006 by AnonymousMy daughter has improved enormously on a specific protocol of supplements, detoxification, and gf/cf, soy free, glutamate free, low sugar diet. It is not idiopathic as she regressed after 165 mcg of thimerosal. She is now being treated for toxic encephalopathy, gut dysbiosis, an inability to excrete heavy metals, immune dysfunction, and food intolerances.
I see nothing on this site about many autistic children having immune and gut dysfunction, nor any studies about inflammation at all.
Autism: A Novel Form of Mercury Poisoning.
Medical Hypothesis, 2001.
Sallie Bernard, Albert Enyati, Lynn Redwood, RN, Teresa Binstock, PhD.
Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal.
Environmental Health Perspectives, Aug 2005.
Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors.
Neurotoxicology, Jan 2005.
S. Jill James, PhD [University of Arkansas].
Large Brains in Autism: The Challenge of Pervasive Abnormality.
The Neuroscientist, Volume 11, Number 5, 2005.
Martha Herbert, MD, PhD [Harvard University].
Neurotoxic Effects of Postnatal Thimerosal are Mouse Strain Dependent.
Molecular Psychiatry, Sep 2004.
Mady Hornig, MD [Columbia University].
Activation of Methionine Synthase by Insulin-like Growth Factor-1 and Dopamine: a Target for Neurodevelopmental Toxins and Thimerosal.
Molecular Psychiatry, July 2004.
Richard C. Deth, PhD [Northeastern University].
Neuroglial Activation and Neuroinflammation in the Brain of Patients with Autism.
Annals of Neurology, Feb 2005.
Diana L. Vargas, MD [Johns Hopkins University].
Reduced Levels of Mercury in First Baby Haircuts of Autistic Children
International Journal of Toxicology
Dr. Amy S. Holmes, Mark F. Blaxill, Boyd E. Haley, Ph.D.
March 14, 2003
Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: Their Relationship to Gastrointestinal Symptoms and Dietary Intervention.
Neuropsychobiology, 2005.
Harumi Jyonouchi, MD [New Jersey Medical School].
http://www.autismwebsite.com/ari/index.htm