Autism Therapy: insulin

definition of insulin: Insulin is a hormone produced in the pancreas. It maintains proper glucose levels in the blood and helps metabolize carbohydrates. If insulin is not produced properly, the result may be diabetes (Type I diabetes). Insulin can be manufactured and delivered via injection or inhaler.

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Journal of Child and Adolescent Psychopharmacology, by Calare, CA, Acion L., Kuperman S., Tansey M., and Schlechte JA, published in 2009, summarized Aug 18, 2009

Risperidone therapy may result in weight gain and metabolism changes in typical children and adolescents and those with pervasive developmental disorder.

This study measured weight and body mass index (BMI) for 99 children and adolescents (7-17 years old). Metabolism tests (measures of how the body uses food and energy) were also performed. The patients had been taking risperidone for nearly 3 years. Only some of the patients had pervasive developmental disorder (PDD). In the total group of patients, 19% were overweight and 15% were obese. The authors compared metabolism test results of the overweight/obese patients with the lean patients. The overweight/obese patients had more abnormal metabolism tests than the lean patients. For example, the overweight/obese patients had higher triglycerides (types of fatty acids) and higher insulin concentrations than the lean patients. However, few of the patients had metabolic syndrome. Metabolic syndrome is a combination of metabolism changes linked to higher risk of heart disease.


Journal of Medical Genetics, by Schmidt, H., Kern W., Giese R., Hallschmid M., and Enders A., published in 2009, summarized May 5, 2009

Intranasal insulin may help some children with autism move better and gain IQ points.

This study was designed to see if squirting insulin into the nose (intranasal) of children with a type of autism (Phelan-McDermid syndrome) would help with the symptoms of autism. The trial involved six children who were treated with intranasal insulin for up to one year. The children were different ages (9 months to 6.5 years) and had different symptoms of the syndrome. Patient three was the least impaired patient (age 3) and she was the only one who had a bad response to the treatment. The authors do not know why the intranasal insulin helped the children.


Chemotherapy, by Riikonen, R., published in 2006, summarized Mar 19, 2007

IGF-1 therapy may help to nurture the brains of children with autism.

IGF hormones are made in the brain. They may help the brain to grow and to protect the brain from damage. Some children with autism have unusually low levels of the hormone IGF-1 in their spinal cord. These low levels of IGF-1 may be causing problems in the brain. IGF-1 is a small molecule that can enter into the brain from the blood and therefore children could theoretically get IGF-1 treatment in the form of a shot.


Journal of Child and Adolescent Psychopharmacology, by Luby, J., Mrakotsky C., Stalets MM, Belden A., Heffelfinger A., Williams M., and Spitsnagel E., published in 2006, summarized Jan 18, 2007

Risperidone may improve autism in preschoolers.

This study was designed to see whether risperidone is a safe and effective treatment for preschoolers with autism. The children were given low doses (0.5-1.5 mg total daily dose) for 6 months. In general, the children treated with risperidone showed improvements in global measures of autism symptoms. Some of the children given risperidone gained weight. The authors note that future studies should test to see whether insulin resistance is a side effect of risperidone treatment in preschoolers.


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Yummy Food or Yucky Food

Sep 11, 2008 by Anonymous

One Person's Yummy Food Is Another Person's Yucky Food

Vegetables and protein (fish, poultry, meats, and beans) are the most common food aversions. Some children even reject fruits. The diet becomes extremely restricted to bland, white foods, including sweets, breads, pasta, crackers, pretzels, chips, and macaroni and cheese. These foods are glycemic and raise blood glucose, quickly increasing the demand for insulin production. Zinc is part of the insulin molecule and is depleted, resulting in abnormal taste and taste perception. What develops is an aversion to the flavors in natural foods and increased cravings for highly sweetened foods and those foods containing MSG. (MSG affects the brain's perception of flavor.) The diet becomes more narrow, and nutritional status declines, resulting in more limited food choices. The white diet and vegetable aversion is common among children in Western cultures due to the high exposure to processed and sweet foods. For children with sensory and developmental issues, the aversions are much more pervasive and serious.

There are three potential contributors that lead to the limited appetite, cravings, and food aversions:

  1. The formation of opiate-like peptides from gluten and milk products, resulting in cravings for the foods that are the sources.
  2. Zinc deficiency or deficiencies in zinc metabolism and function. Zinc is responsible for sensory development and function, including taste and taste perception.
  3. The presence of toxic metals that can interfere with sensory development and function.

The negative effect of this combination can result in faulty messages from the sensory receptors to the brain and dysfunctional interpretation of those messages by the brain. Perception is the "truth" for that person. This is why begging, bribing, and punishing do not and will not work.

The solution is multifaceted. Correction of nutritional deficiencies and elimination of toxic metals are mandatory and involve appropriate therapeutic supplementation based on findings. Foods that cause reactions and/or opiate-like peptides need to be eliminated as healthy, safe foods are introduced and accepted.

How to Go from Yucky to Yummy-The Trojan Horse Technique

For those with texture issues, it is important to adapt the diet to the child's oral and food developmental stage. If textures are a sensory issue, no matter how tasty the food, it will not be consumed. By providing the food in a sensory-pleasing form, the child benefits nutritionally and begins to find mealtime more pleasant and rewarding. Purees are generally helpful. They are better tolerated and can open the door for getting more types of foods into the diet. Many family dishes, including soups, casseroles, or the meat and vegetable main dish, can also be served pureed for the child who has sensory texture issues. In this way, the whole family is enjoying the same meal.

Many of the recipes in this book have been selected to expand nutritional intake, especially using the Trojan Horse Technique-hiding a small amount of the new food (especially vegetables and proteins) within a very well tolerated and acceptable food. Each child differs and, therefore, it is important to identify what foods will work as "carriers" to get the new foods in.

Purees can be made from cooked fresh or frozen vegetables and/or purchased baby foods. If your child is offended by being served baby food, simply keep it well hidden. Create interesting new names for the foods and see that others in the family join in consuming them. The secret to success in introducing these new foods is to combine a small amount with the food the child already likes. For many children, this is the only way new foods can be introduced.

Start with 1 tablespoon (15 g) or less-and then increase when tolerated. Hide the cooked vegetable purees anywhere you can, selecting colors that are not obvious when added to the carrier food. The carrier food needs to be one that the child enjoys. It may even be a food that is being slowly eliminated. Include pureed fruits to improve the taste. Here are some examples of places to hide foods (and even supplements):

  • Spaghetti Sauce. Blend the pureed vegetables thoroughly with at least three times as much spaghetti sauce; then hand-mix the new blend in with the rest of the sauce. Carrots, beets, sweet potatoes, turnips, squash, green beans, and peas are easy to hide in spaghetti sauce. Watch the amount of green if it is a food color that your child rejects.
  • Muffins, Cakes, and Brownies. Well·pureed foods are easy to hide in these batters, including pureed chicken and turkey. A chicken/vegetable/fruit muffin becomes a healthy meal!
  • Pancakes. Not only can pureed vegetables and fruits hide well in the batter, but they are also a good hiding place for supplements such as protein powders, calcium, magnesium, and zinc.
  • Peanut Butter. If a child likes peanut butter, it is an excellent medium for adding small amounts of protein and nutritional supplements.
  • Meatballs. If these are well liked, especially with spaghetti sauce, the job becomes a whole lot easier. Well-pureed vegetables and fruits are an excellent thickener/filler for meatballs. Make many and freeze them, and then bring them out for snacks.
  • Juices, especially those with a strong flavor, such as pineapple juice, grape juice, nectars, apple cider, and orange juice.
  • Smoothies, Fruit Purées, and Applesauce. These offer an unlimited opportunity for expanding nutrition and an excellent way to hide supplements. Protein powders can be included to expand protein intake, especially for those with texture issues who avoid meat, beans, and other sources of protein. Always start with the fruit your child favors and then expand.
  • Let chocolate be your friend. There are sources of GFCF chocolate chips, sauces, powders, and so forth. Check the product search section of the GFCF Diet site (www.gfcfdiet.com/directory.htm).
  • Add unflavored gelatin to cooked purees to lend more substance and improve digestion.

The above is an excerpt from the book The Kid-Friendly ADHD & Autism Cookbook: The Ultimate Guide to the Gluten-Free, Casein-Free Diet
by Pamela J. Compart, M.D. and Dana Laake, R.D.H., M.S., L.D.N.
Published by Fair Winds Press; November 2006;$24.95US/$32.50CAN; 978-1-59233-223-6
Copyright © 2008 Pamela J. Compart, M.D. and Dana Laake, R.D.H., M.S., L.D.N

Author Bio
Pamela J. Compart, M.D., is a developmental pediatrician in Columbia, Maryland. She combines traditional and complementary medicine approaches to the treatment of ADHD, autism, and other behavioral and developmental disorders. She is also the director of HeartLight Healing Arts, a multidisciplinary integrated holistic health care practice, providing services for children, adults, and families.

Dana Godbout Laake, R.D.H., M.S., L.D.N., is a licensed nutritionist in Kensington, Maryland. Within her practice, Dana Laake Nutrition, she provides preventive and therapeutic medical nutrition services. Her practice includes nutritional evaluation and treatment of the full spectrum of health issues affecting adults and children with special needs.


Biomedical Treatments

Oct 25, 2006 by Anonymous

My daughter has improved enormously on a specific protocol of supplements, detoxification, and gf/cf, soy free, glutamate free, low sugar diet. It is not idiopathic as she regressed after 165 mcg of thimerosal. She is now being treated for toxic encephalopathy, gut dysbiosis, an inability to excrete heavy metals, immune dysfunction, and food intolerances.

I see nothing on this site about many autistic children having immune and gut dysfunction, nor any studies about inflammation at all.

Autism: A Novel Form of Mercury Poisoning.
Medical Hypothesis, 2001.
Sallie Bernard, Albert Enyati, Lynn Redwood, RN, Teresa Binstock, PhD.

Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal.
Environmental Health Perspectives, Aug 2005.

Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors.
Neurotoxicology, Jan 2005.
S. Jill James, PhD [University of Arkansas].

Large Brains in Autism: The Challenge of Pervasive Abnormality.
The Neuroscientist, Volume 11, Number 5, 2005.
Martha Herbert, MD, PhD [Harvard University].

Neurotoxic Effects of Postnatal Thimerosal are Mouse Strain Dependent.
Molecular Psychiatry, Sep 2004.
Mady Hornig, MD [Columbia University].

Activation of Methionine Synthase by Insulin-like Growth Factor-1 and Dopamine: a Target for Neurodevelopmental Toxins and Thimerosal.
Molecular Psychiatry, July 2004.
Richard C. Deth, PhD [Northeastern University].

Neuroglial Activation and Neuroinflammation in the Brain of Patients with Autism.
Annals of Neurology, Feb 2005.
Diana L. Vargas, MD [Johns Hopkins University].

Reduced Levels of Mercury in First Baby Haircuts of Autistic Children
International Journal of Toxicology
Dr. Amy S. Holmes, Mark F. Blaxill, Boyd E. Haley, Ph.D.
March 14, 2003

Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: Their Relationship to Gastrointestinal Symptoms and Dietary Intervention.
Neuropsychobiology, 2005.
Harumi Jyonouchi, MD [New Jersey Medical School].

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