Risperidone therapy may result in weight gain and metabolism changes in typical children and adolescents and those with pervasive developmental disorder.
This study measured weight and body mass index (BMI) for 99 children and adolescents (7-17 years old). Metabolism tests (measures of how the body uses food and energy) were also performed. The patients had been taking risperidone for nearly 3 years. Only some of the patients had pervasive developmental disorder (PDD). In the total group of patients, 19% were overweight and 15% were obese. The authors compared metabolism test results of the overweight/obese patients with the lean patients. The overweight/obese patients had more abnormal metabolism tests than the lean patients. For example, the overweight/obese patients had higher triglycerides (types of fatty acids) and higher insulin concentrations than the lean patients. However, few of the patients had metabolic syndrome. Metabolic syndrome is a combination of metabolism changes linked to higher risk of heart disease.









Please comment on this autism topic.
Yummy Food or Yucky Food
Sep 11, 2008 by AnonymousOne Person's Yummy Food Is Another Person's Yucky Food
Vegetables and protein (fish, poultry, meats, and beans) are the most common food aversions. Some children even reject fruits. The diet becomes extremely restricted to bland, white foods, including sweets, breads, pasta, crackers, pretzels, chips, and macaroni and cheese. These foods are glycemic and raise blood glucose, quickly increasing the demand for insulin production. Zinc is part of the insulin molecule and is depleted, resulting in abnormal taste and taste perception. What develops is an aversion to the flavors in natural foods and increased cravings for highly sweetened foods and those foods containing MSG. (MSG affects the brain's perception of flavor.) The diet becomes more narrow, and nutritional status declines, resulting in more limited food choices. The white diet and vegetable aversion is common among children in Western cultures due to the high exposure to processed and sweet foods. For children with sensory and developmental issues, the aversions are much more pervasive and serious.
There are three potential contributors that lead to the limited appetite, cravings, and food aversions:
The negative effect of this combination can result in faulty messages from the sensory receptors to the brain and dysfunctional interpretation of those messages by the brain. Perception is the "truth" for that person. This is why begging, bribing, and punishing do not and will not work.
The solution is multifaceted. Correction of nutritional deficiencies and elimination of toxic metals are mandatory and involve appropriate therapeutic supplementation based on findings. Foods that cause reactions and/or opiate-like peptides need to be eliminated as healthy, safe foods are introduced and accepted.
How to Go from Yucky to Yummy-The Trojan Horse Technique
For those with texture issues, it is important to adapt the diet to the child's oral and food developmental stage. If textures are a sensory issue, no matter how tasty the food, it will not be consumed. By providing the food in a sensory-pleasing form, the child benefits nutritionally and begins to find mealtime more pleasant and rewarding. Purees are generally helpful. They are better tolerated and can open the door for getting more types of foods into the diet. Many family dishes, including soups, casseroles, or the meat and vegetable main dish, can also be served pureed for the child who has sensory texture issues. In this way, the whole family is enjoying the same meal.
Many of the recipes in this book have been selected to expand nutritional intake, especially using the Trojan Horse Technique-hiding a small amount of the new food (especially vegetables and proteins) within a very well tolerated and acceptable food. Each child differs and, therefore, it is important to identify what foods will work as "carriers" to get the new foods in.
Purees can be made from cooked fresh or frozen vegetables and/or purchased baby foods. If your child is offended by being served baby food, simply keep it well hidden. Create interesting new names for the foods and see that others in the family join in consuming them. The secret to success in introducing these new foods is to combine a small amount with the food the child already likes. For many children, this is the only way new foods can be introduced.
Start with 1 tablespoon (15 g) or less-and then increase when tolerated. Hide the cooked vegetable purees anywhere you can, selecting colors that are not obvious when added to the carrier food. The carrier food needs to be one that the child enjoys. It may even be a food that is being slowly eliminated. Include pureed fruits to improve the taste. Here are some examples of places to hide foods (and even supplements):
The above is an excerpt from the book The Kid-Friendly ADHD & Autism Cookbook: The Ultimate Guide to the Gluten-Free, Casein-Free Diet
by Pamela J. Compart, M.D. and Dana Laake, R.D.H., M.S., L.D.N.
Published by Fair Winds Press; November 2006;$24.95US/$32.50CAN; 978-1-59233-223-6
Copyright © 2008 Pamela J. Compart, M.D. and Dana Laake, R.D.H., M.S., L.D.N
Author Bio
Pamela J. Compart, M.D., is a developmental pediatrician in Columbia, Maryland. She combines traditional and complementary medicine approaches to the treatment of ADHD, autism, and other behavioral and developmental disorders. She is also the director of HeartLight Healing Arts, a multidisciplinary integrated holistic health care practice, providing services for children, adults, and families.
Dana Godbout Laake, R.D.H., M.S., L.D.N., is a licensed nutritionist in Kensington, Maryland. Within her practice, Dana Laake Nutrition, she provides preventive and therapeutic medical nutrition services. Her practice includes nutritional evaluation and treatment of the full spectrum of health issues affecting adults and children with special needs.
Biomedical Treatments
Oct 25, 2006 by AnonymousMy daughter has improved enormously on a specific protocol of supplements, detoxification, and gf/cf, soy free, glutamate free, low sugar diet. It is not idiopathic as she regressed after 165 mcg of thimerosal. She is now being treated for toxic encephalopathy, gut dysbiosis, an inability to excrete heavy metals, immune dysfunction, and food intolerances.
I see nothing on this site about many autistic children having immune and gut dysfunction, nor any studies about inflammation at all.
Autism: A Novel Form of Mercury Poisoning.
Medical Hypothesis, 2001.
Sallie Bernard, Albert Enyati, Lynn Redwood, RN, Teresa Binstock, PhD.
Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal.
Environmental Health Perspectives, Aug 2005.
Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors.
Neurotoxicology, Jan 2005.
S. Jill James, PhD [University of Arkansas].
Large Brains in Autism: The Challenge of Pervasive Abnormality.
The Neuroscientist, Volume 11, Number 5, 2005.
Martha Herbert, MD, PhD [Harvard University].
Neurotoxic Effects of Postnatal Thimerosal are Mouse Strain Dependent.
Molecular Psychiatry, Sep 2004.
Mady Hornig, MD [Columbia University].
Activation of Methionine Synthase by Insulin-like Growth Factor-1 and Dopamine: a Target for Neurodevelopmental Toxins and Thimerosal.
Molecular Psychiatry, July 2004.
Richard C. Deth, PhD [Northeastern University].
Neuroglial Activation and Neuroinflammation in the Brain of Patients with Autism.
Annals of Neurology, Feb 2005.
Diana L. Vargas, MD [Johns Hopkins University].
Reduced Levels of Mercury in First Baby Haircuts of Autistic Children
International Journal of Toxicology
Dr. Amy S. Holmes, Mark F. Blaxill, Boyd E. Haley, Ph.D.
March 14, 2003
Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: Their Relationship to Gastrointestinal Symptoms and Dietary Intervention.
Neuropsychobiology, 2005.
Harumi Jyonouchi, MD [New Jersey Medical School].
http://www.autismwebsite.com/ari/index.htm