Autism Therapy: irritability

definition of irritability: not yet defined.

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Journal of Child and Adolescent Psychopharmacology, by Stigler, KA, Diener JT, Kohn AE, Li L., Erickson CA, Posey DJ, and McDougle CJ, published in 2009, summarized Jul 22, 2010

Aripiprazole may help to improve severe irritability in children with pervasive developmental disorder not otherwise specified (PDD-NOS) and Asperger syndrome.

This prospective, open-label study sought to find out if the drug aripiprazole was safe and helpful as a treatment for irritability in children with PDD-NOS and Asperger syndrome. The 14-week study found that aripiprazole was safe and may be helpful for such patients. The patients showed decreased irritability as well as increased social behavior. The authors note that there are not many studies of patients with PDD-NOS (as opposed to autism). PDD-NOS is the most common subtype of PDD and the authors called for more studies of these patients.


J Am Acad Child Adolesc Psychiatry, by Marcus, RN, Owen R., Kamen L., Manos G., McQuade RD, Carson WH, and Aman MG, published in 2009, summarized May 13, 2010

Aripiprazole may help to treat irritability in children with autism.

This double-blind, placebo-controlled study compared the atypical antipsychotic aripiprazole with placebo in terms of being able to reduce irritability in children (aged 6 to 17 years) with autism. This eight week study found that aripiprazole was able to reduce irritability in children with autism. Children who received aripiprazole also had decreased hyperactivity. There was a high placebo response rate of 35% on this study. The authors also note that this was a fixed-dose study and therefore doctors were not able to change the dose of the drug based upon the patient’s response to the drug.


Expert Opinion, by Kavirajan, H., published in 2009, summarized Dec 21, 2009

Memantine may be helpful for people with moderate-to-severe autism disorders.

The glutamate pathway may be out of balance in brains of people with autism. Memantine is a medication that reduces certain brain activities by blocking glutamate receptors in the brain. Two clinical trials of memantine in people with autism had different results. One trial reported that memantine was helpful for improving language and social interactions in people with pervasive developmental disorder-not otherwise specified (PDD-NOS). Another trial reported improvements in memory, irritability, and other behaviors for people with PDD. However, language was not affected in the second trial. Neither of these studies included a placebo control. Better studies are needed to find out if memantine may be helpful for people with autism.


Pharmacopsychiatry, by Roser, P., Haubleiter IS, Juckel G., and Brune M., published in 2009, summarized Jul 9, 2009

Treatment with paliperidone helped an adult with Asperger Syndrome who had severe behavioral problems and autism symptoms.

The case report said 25-year-old man had severe anxiety, delusions (not in touch with reality), irritability, and other problems. He also had poor communication and social skills. He was admitted to a hospital because of his severe symptoms, and was diagnosed with Asperger Syndrome. He received 6 mg daily of paliperidone, which is related to risperidone. The drug therapy reduced his symptoms. He also had better social skills. After 4 months of treatment, he improved so much that he moved out of his parent's house to live in an apartment of his own. He had few side effects from the paliperidone treatment.


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Please comment on this autism topic.

In 2006 the FDA approved risperidone for the specific treatment of aggression and irritability in people (inc children) with autism, yet you have posted an expert opinion also from 2006 that anti-psychotics are not useful in treating autism. Please review your information. Risperidone is an anti-psychotic and has been found to be effective in treating patients with autism who are easily agitated and frequently aggressive. While I can not speak specifically to Thorazine, the professional opinion used to back up the information is outdated and no longer correct. 


Comment added from Healing Thresholds: Note that rarely is scientific consensus achieved in one year. Moreover, scientific consensus rarely occurs as the result of a regulatory decision (FDA approval). At Healing Thresholds we summarize medical research as it occurs and we provide the date of the medical research/medical opinion. We inlude both mainstream and alternative views as long as those studies/opinons have been subjected to the scientific peer review process. We encourage all readers to consider the date of the research/opinion (and the source of the research/opinion) when evaluating how the results relate to their own child's therapy program.


School Lunches for Kids with ASD

Sep 11, 2008 by Anonymous

SCHOOL LUNCHES FOR KIDS WITH ASD: DELICIOUS, HEALTHY & POSSIBLE.

THE CHALLENGE:

With only twenty minutes to eat, kids with autism spectrum disorder (ASD) should have "fast" foods that are healthy, tasty, loaded with nutrients and free of the culprits that are common problems: gluten, milk products, soy, and artificial additives and coloring. Add to the list sensory issues involving food texture, color and taste along with unusually picky appetites so common in ASD - and the task seems insurmountable. Beyond the challenges with foods are the safety issues of the food containers themselves, especially plastics containing phthalates and bisphenyl A (BPA). And of course there is the "cool" factor which affects pre-school through high school. Food that is different is totally uncool for kids who already face so many social and learning stigmas.

Knowing the challenges, we can now focus on the solutions.

THE SOLUTIONS:

Basics

As is the case with any meal, there are some basics to follow. Blood sugar control is critical. All people are affected by rapidly rising blood sugar which then cascades down too quickly and too low. The most noticeable effects are on brain function especially mood and attention. As the blood sugar drops too quickly, there can be irritability, hunger headaches, lack of focus, behavior problems, and cravings for a "quick sugar fix" which keeps the cycle going. This interferes with learning and can be disruptive to the class. Protein and fiber stabilize blood sugars. Below is a summary of the basic rules for any meal including school lunch.

Assumptions

All food suggestions are GFCF (gluten-free, casein-free). Glutens include wheat, oat, barley, rye, spelt and kamut. Milk products and milk casein include milk, yogurt, cheese, creams, ice cream, cream sauces, and butter.

Avoids

Glycemic foods which raise blood sugar (glucose) quickly include: sugars, sodas of any kind, candy, sweets, juices, and any refined grains (pretzels, bread, crackers, bagels, chips) on an empty stomach. Limit the sugars and keep the refined carbohydrates limited. If small amounts are consumed at the end of the meal, the negative effect is less.

A word on sodas - both regular and diet. They have no place in a healthy diet. They are high in phosphorus which depletes healthy nutrients. Consider them removers of electrolytes, not drink options. Water is best, but other good choices include: dilute juices, seltzer water with juice to flavor, vegetable juices (V8)

Promote Protein at every meal or snack

Choices include fish, poultry, meat, eggs, beans, nuts and seeds.

Avoids: milk products

The serving size for protein for each person is the size of the palm. A child's may be 1 to 2 ounces of meat/chicken/fish and a teen and adult may be 3 to 5 ounces. See the chart for guidelines

For beans, the serving size is two cupped palms full. See the chart for guidelines.

Fabulous Fiber at every meal

Choices include fruits, beans, nuts, seeds and grains.

Avoid: glutens

If your child eats very few vegetables, fruits, grains, nuts, seeds and beans, added fiber is important. Fiber as pure guar gum is easy to add to any recipe and also to drinks. It is GFCF and more fine than sugar, mixing completely in water or juice. See the table for fiber intake suggestions.

Favorite Foods at every meal or snack

Include at least one food that is a favorite in order to promote more interest in the meal.

Fun Meals - Part of the Cool Factor

Take a tip from the fast food marketers and include a surprise gift in the lunch. It might be a small collectible such as cars, baseball cards, characters, hair clips, stickers, or child's ring or bracelet. Home made "giftlets" (tiny gifts) are perfect.

Guidelines and Ideas

Go organic as much as possible. "USDA Organic" means the food is produced without the use of harmful pesticides, artificial fertilizers, antibiotics, growth hormones human waste, or sewage sludge, and that they were processed without ionizing radiation or food additives. Children with ASD are already coping with their own excess metabolites and really can not handle the burden of harmful chemicals in the environment and foods. The less the exposure the better. Anything you can do for your child is a benefit.

There are numerous resources for GFCF foods and recipes online and in many books. Utilize all of these to find the commercially available foods your child will eat as well as recipes that are not just GFCF, they are nutritious and delicious. Test them at home - not in the school lunch. There are GFCF juice boxes, pretzels, breads, wraps and snacks.

Establish three to five basic lunches that work. If your child is willing and interested, engage him or her in the process. Test new foods out at home until you have the food right and the combination of foods right.

Use freezer packs for keeping foods cold and thermos for hot foods. Include non-toxic hand sanitizers which are commercially available (avoid the commercial sanitizers). You can also send two paper towel pieces - one moistened with soap and one moistened with water..

Packaging - a good opportunity to Go Green!

Again - go with the marketers - jazz it up! Select a lunch container your child loves. Young children love to decorate a lunch box with stickers and paints. Make the lunch box the child's own work of art personalized with a name. Reusable containers and boxes are the green way to go. Older children will definitely want to select whatever is considered cool. The most cool may be a paper bag or small recycled bag carried in a back pack. Go with the trend and your child's own choice. There are companies who make safe, BPA-Free, safe lunch box sets with inserts for the different foods.

To avoid plastic wraps for sandwiches, use wax paper or parchment paper. Avoid containers with BPA by avoiding items with the recycle number 7. There are many BPA -Free containers which can be washed and reused. Your child will need to know to bring these back home rather than throw them away.

For napkins, use washable cloth napkins or dishcloths, or choose processed chlorine-free (PCF), post-consumer-waste (PCW) paper napkins available in stores and on line. If utensils are needed, use stainless steel appropriate to the child's skill level and age.

Nutritious Can Be Delicious - Even for the Picky Eater - The Trojan Horse Technique

Remember Odysseus from seventh grade mythology? Seeking to gain entrance into Troy, he cleverly ordered a hollow wooden horse so large that the Greek army could hide inside. What looked like a huge horse was really a disguise to conquer the city. We have used this concept for decades to hide nutritious food to nourish picky eaters.

Rather than introduce a new food in its natural form, begin by hiding a very small amount (about a tablespoon) of it as puree mixed or blended into a well-liked and well-tolerated food. This approach allows the body to accept the new food. As the child accepts the taste, include more. Children who have food texture issues are especially good candidates for blended foods because their sensory development may be younger than their chronological age. Adapt to the sensory level and return to purees until sensory issues improve. Rather than focusing on getting a child to tolerate foods that he perceives as "lumpy" or unpleasant to chew, the goal is getting a child to eat nutritious food, however you can.

Match the Color and Texture

Assume the new food is a vegetable, use organic baby food purees or make your own. Puree the new food into an established food that does not change the overall color, texture, smell, or taste. If a child eats nothing but white food, start with very light-colored vegetables including squash, cauliflower and corn. If the child likes ketchup or tomato sauce, then introduce deeper-colored vegetables such as beets, greens, peas and beans. Pureed vegetables can be beaten into batter for pancakes, muffins, brownies, and cookies or into tomato and other pasta and pizza sauces, and even into ketchup.

Mix Fruits and Vegetables

Vegetable juice makes a healthy addition to fruit juice. Try mixing carrot juice with orange juice, and then adding a teaspoon or so of another vegetable juice. Serve in a brightly colored sippy cup to camouflage any color changes. Blend pureed vegetables into cooked fruits such as applesauce or pearsauce, into meatballs, and even into nut butters. Expand ideas as tolerance improves. Be sure to carry out the Trojan Horse technique out of the sight of your child!

Muffin Casseroles

Many families have developed what we call muffin casseroles. One resourceful mother developed a GF/CF muffin for her child who ate only breads and muffins, and then gradually added fruit puree to the batter. As he tolerated fruits, she moved to vegetable purees, and finally added pureed meat. Until he was able to transition to eating foods in a traditional manner, he ate his muffin casseroles at every meal and snack-and loved them!

Increase Protein

The Trojan Horse technique is especially useful for kids who need more protein in their diets. Add eggs, especially the high-protein whites, and rice-protein powders to batters, breads, smoothies, meat sauces and meatballs. Do not add raw eggs to smoothies.

Gradually Move On

AS your child expands to eating vegetables, try vegetables dipped in honey or mayo/ketchup mix or hommus. It is a start . As a child accepts an increasing number of foods presented in a sneaky manner, eventually, he/she will accept the food alone - we promise! All it takes is patience, and a lesson from Greek mythology!

Choose one from each section. This list is GFCF. Also avoid any foods which provoke reactions or those forbidden at school (nuts for examples) or foods The "Other" section is optional.

Some Protein Choices: chicken strips, GFCF chicken nuggets w/ketchup to dip, meat slices rolled up, shrimp (send frozen, will thaw by lunch) w/seafood sauce to dip, organic "deli" chicken slices, hommus plain, on bread or crackers or as dip for veggies, muffin "pot pies", soy yogurt, egg salad, hard boiled eggs or deviled eggs, peanut butter on crackers or apples, nuts - all varieties - almonds, cashews, pecans, pistachios, hazelnuts. Hot food for thermos: chili or soups, turkey hot dogs cut up, GFCF pizza.

Some Vegetables & Fruit Choices: These can be eaten plain or dipped in GFCF sauces, ketchup or honey. Foods include: cup of vegetables, baby carrots or carrot strips, broccoli "trees", apples, bananas, berries, oranges, peaches, grapes, pineapple, melon, natural fruit cocktail in natural juice, raisins, apricots,  applesauce in cups, any blended fruit sauce.

Drink Choices: water, fruit juice, V8, V8+fruit, seltzer w/juice, fruit smoothie, other milk (soy, rice, coconut, almond), and keep drinks partially frozen so they will remain cold. 
Other: GFCF pretzels, rice crackers, baked tortilla chips, GFCF dry cereal, GFCF vegetable gummies, small GFCF cookie.

The above is an excerpt from the book The Kid-Friendly ADHD & Autism Cookbook: The Ultimate Guide to the Gluten-Free, Casein-Free Diet
by Pamela J. Compart, M.D. and Dana Laake, R.D.H., M.S., L.D.N.
Published by Fair Winds Press; November 2006;$24.95US/$32.50CAN; 978-1-59233-223-6
Copyright © 2008 Pamela J. Compart, M.D. and Dana Laake, R.D.H., M.S., L.D.N

Author Bio
Pamela J. Compart, M.D., is a developmental pediatrician in Columbia, Maryland. She combines traditional and complementary medicine approaches to the treatment of ADHD, autism, and other behavioral and developmental disorders. She is also the director of HeartLight Healing Arts, a multidisciplinary integrated holistic health care practice, providing services for children, adults, and families.

Dana Godbout Laake, R.D.H., M.S., L.D.N., is a licensed nutritionist in Kensington, Maryland. Within her practice, Dana Laake Nutrition, she provides preventive and therapeutic medical nutrition services. Her practice includes nutritional evaluation and treatment of the full spectrum of health issues affecting adults and children with special needs.


Carnitine fumarate

Mar 23, 2007 by Anonymous

My son has Prader-Willi Syndrome and I know this is different from autism. I am posting this entry here, though, because his response to carnitine fumarate is really amazing. His OT was really impressed with how it has improved his processing speed. It works by improving fatty acid metabolism. Fatty acid metabolism is an area of active research for autism therapy. There doesn't really seem to be a downside to giving carnitine fumarate (other than diarrhea).

The text below is lifted from www.PWSNotes.org

 

So, what is L-carnitine _fumarate_? Most L-carnitine sold by supplement manufacturers is either L-carnitine hydrochloride or L-carnitine _tartrate_ (L-carnitine bound to tartrate). With L-carnitine _fumarate_ (which was developed and patented by Sigma Tau, the maker of Carnitor), the carnitine is bound to fumarate, which is a key substrate in what is called the Kreb's cycle in mitochondria for the production of energy. It is the Kreb's cycle that produces the electrons that are then passed along respiratory transport chain complexes 1-IV for the production of ATP (the basic cellular form of energy). Citrate synthase is the key enzyme involved in the first step of the Kreb's cycle and as such can be rate-limiting for the whole cycle. Fumarate, though, is the substrate for the next to last step in the Krebs cycle and its related enzyme is fumarase.

About 58% of L-carnitine fumarate is L-carnitine, with the rest being fumarate. After it is ingested, the body separates the L-carnitine from the fumarate. Although I can't say for sure at this point, what might be happening is that the L-carnitine part is going off and doing all of the good things it is known for in terms of transporting fatty acids into the mitochondria for burning for energy and whatnot, while the fumarate is entering the Kreb's cycle and boosting its output of electrons that are then transferred to the electron transport chain, resulting in an increase in the production of cellular energy in the form of ATP. If that's what is happening, it could be the extra fumarate is providing a pathway around a metabolic block, possibly in succinate dehydrogenase (SDH), given that SDH is the enzyme that catalyzes the succinate-to-fumarate reaction. If so, it could be that the impairment in respiratory chain transport is not a primary event but is instead a downstream result of reduced substrate availability in the Kreb's cycle. (Interestingly, fumarase deficiency is a very rare autosomal recessive disorder in which the metabolizing of fumarate in the Kreb's cycle is sharply reduced or completely absent and is characterized by massive secretion of fumarate in the urine, encephalopathy, hypotonia and severe developmental delays, all of which (aside from excessive fumarate secretion) are rather reminiscent of another syndrome that we are all too familiar with.)

The Pure Caps capsules contain 586 mg of L-carnitine fumarate, with 340 mg of that being L-carnitine and 246 mg being fumarate. Sulli is only getting 1/4 capsule a day, which works out to about 85 mg of L-carnitine and 60 mg of fumarate for a 16 lb (7.25 kg) baby, which is about 12 mg/kg/day of L-carnitine and 8 mg/kg/day of fumarate. That's a surprisingly small amount of L-carnitine to be providing such dramatic benefit, given that the recommended dosage range for Carnitor is 35-50 mg/kg/day, and provides further support for the hypothesis that the fumarate part could be providing a significant amount of the benefit.

I've spent some time looking into the safety of L-carnitine fumarate and fumarate. L-carnitine fumarate is a relatively new form of carnitine and there aren't many clinical studies involving its use. The studies I found all have to do with Sigma Tau's patented formula for male infertility, ProXeed (yes, among other things, carnitine helps sperm swim better :-). The daily dose of that formula contains 2 g/day of L-carnitine fumarate, 1 g/day of acetyl-l-carnitine, 4 g/day of fructose and an unspecified amount of citric acid (which is also a metabolite in the Kreb's cycle), and in clinical trials seems to have been very well tolerated aside from the usual occasional side effects of large doses of carnitine (i.e., transient nausea and digestive upset, loose stools, etc.).

I have not been able to find any reports of fumarate being used as a supplement. However, fumarate is a component of ferrous fumarate (used globally for iron deficiency anemia in children and adults), as well as a number of drugs, including quetiapine and retroviral inhibitors such as tenofovir. In general it seems to be a safe substance (although it probably shouldn't be used by those with fumarase deficiency).

So what's the bottom line here? It could be that the L-carnitine vs. acetyl-l-carnitine question will become moot and the L-carnitine fumarate form could become the carnitine of choice for those with PWS.

For those who are interested in trying L-carnitine fumarate, the Pure Caps page for it is at http://www.purecaps.com/itemdy00.asp?T1=LCF1, with supplementary information at http://www.purecaps.com/PDF/pi/l_Carnitine_Fumarate.pdf. Jarrow also has (http://www.jarrow.com/product.php?prodid=191), as does Doctor's Best (http://www.drbvitamins.com/nutritionalproducts_details.asp?id=16). Make sure the label specifies that the L-carnitine is the fumarate form and not the more commonly available L-carnitine tartrate. All of the L-carnitine fumarate on the market is made by Sigma Tau and is pharmaceutical grade.

Please note that I am in the process of revising the carnitine and Coenzyme Q10 articles to suggest that, especially for older children, carnitine and/or CoQ10 supplementation be started with very low doses and then very slowly increased in order to give the child (and their parents) plenty of time to adapt to more normal levels of mental and physical energy. After all, older children with PWS have lived with a significant mental and physical energy deficit for years and to them that is "normal." Then CoQ10 or carnitine is started, and all of a sudden the world is a brighter, busier place, they're experiencing all kinds of new perceptions and sensations, and their thinking is zipping along at a significantly faster pace. It's probably much like going from a dim room out into bright sunlight, except way more intense because the increase in energy they're experiencing is a full body and mind experience. So it's not surprising that it could be a somewhat disorienting experience that could lead to emotional, mental and physical reactions that others interpret as irritability. I therefore consider it important that the increase in mental and physical energy provided by CoQ10 and/or carnitine be increased very slowly so as to give the child and their parents plenty of time to adapt, physically, mentally and emotionally, to each step up to a higher level of energy as the dose is slowly increased. It will also probably be helpful if the parents talk with the child ahead of time about what kinds of things they might experience when the CoQ10 or carnitine.

I think the need to proceed very slowly is somewhat less of an issue for infants and toddlers, especially those who are badly delayed in such things as babbling and talking, head control, sitting, and walking, as they have not spent nearly as much time entrained by a significant energy deficit and I think it is important to get them developmentally on track as soon as possible. But as always, it is critical that parents use their intimate knowledge of their child and intuition in determining the approach that will be best for their child.

I also need to note that there is the possibility that the irritability reported in some of those with PWS when CoQ10 supplementation is started could be due to the increased energy unmasking an intrinsic behavioral disturbance that was previously "sedated" by a serious impairment in cellular energy availability. At this point I have no way of determining how much of that irritability could be the result of a some level of understandable disorientation due to a sudden increase in mental and physical energy (as described above) or is due to an unmasking effect. If it does turn out that CoQ10, carnitine, or anything else that improves energy metabolism and mitochondrial function in PWS to more normal levels can unmask a previously sedated behavioral disturbance, I think there are ways that could be dealt with, but that is beyond the scope of this post. I will note once again, though, that my hunch is that at least some of the severe behavioral problems associated with PWS are due to (1) chronic intermittent hypoxia and sleep fragmentation caused by under- or untreated breathing disorders, and/or (2) untreated energy metabolism problems that lead to repeated episodes of hypoglycemia, which is well-known to cause severe irritability and anxiety as well as psychotic-like symptoms and out-of-control rages. I therefore consider it essential that any breathing disorder be aggressively treated and every effort made to ensure stable blood sugar levels throughout the day.

 


Risperdal

Feb 23, 2007 by Anonymous

In October 2006, the FDA approved the use of Risperdal (risperidone) for the treatment of irritability associated with autistic disorder. This means that it can be used to treat aggression towards self and towards others, temper tantrums, and rapidly changing moods. This is the first drug approved for children (aged 5-16) with autism.



Please comment on irritability or other autism therapy topics.

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