Autism Therapy: lethargy

definition of lethargy: not yet defined.

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Risperidone Improves Behavioral Symptoms in Children with Autism in a Randomized, Double-Blind, Placebo-Controlled Trial
J Autism Dev Disord, by Pandina, GJ, Bossie CA, Youssef E., Zhu Y., and Dunbar F., published in 2007, summarized May 18, 2007

Risperidone treatment can help with bad behavior in children with pervasive developmental disorder (PDD).

Risperidone is the best studied of the drug therapies used to treat problems found in people with autism. This study was designed to test the whether or not risperidone is safe and helpful for treating bad behavior in children with autism. The study had 55 children aged 5-12 years and lasted for eight weeks. Children given risperidone therapy were better behaved and had less irritability, lethargy/social withdrawal, and hyperactivity. There were no major side effects from treatment with risperidone.


Improvement in Children with Autism Treated with Intravenous Gamma Globulin
Journal of Nutritional and Environmental Medicine, by Boris, M., Goldblatt A., and Edelson SM, published in 2006, summarized Nov 22, 2006

Monthly treatment with intravenous gamma globulin (IVIG) may improve hyperactivity, inappropriate speech, irritability, lethargy, and stereotypy in children with autism.

This open retrospective study included 27 children with autism, who had failed to show improvement with dietary elimination of dairy and gluten, vitamin and mineral supplementation, and behavioral educational therapies. Previous studies have suggested that children with autism may have immunological disorders. The group of children in this study had many signs of an overly strong immune response including a high level of antibodies to myelin basic protein, thyroid, and DNA. IVIG is an approved immunological therapy that is considered to be safe for individuals with autoimmune diseases. The authors found that IVIG therapy for six months resulted in improvement in all measured aberrant behaviors.


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