Autism Therapy: mercury

definition of mercury: not yet defined.

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BMC Clinical Pharmacology, by Adams, JB, Baral M., Geis E., Mitchell J., Ingram J., Hensley A., Zappia I., and Newmark S., published in 2009, summarized Apr 27, 2010

A single round of DMSA chelation therapy may improve the severity of autism.

The purpose of this study was to see if DMSA therapy is safe and helpful for children with autism. The authors used five tools to assess changes in autism symptoms. Three of the tools (PDD-BI, SAS and PGI) showed improved behaviors in the children who were given one round of DMSA therapy, and those who were given seven rounds of DMSA therapy. The authors believe that one round of treatment may be enough for some children to excrete toxic metals. The children who released the most metals (thallium, arsenic, mercury, and lead) were the ones with the most improved autism symptoms.


Journal of Toxicology and Environmental Health, Part A, by Geier, DA, and Geier MR, published in 2007, summarized Nov 5, 2007

Chelation therapy may decrease the amount of porphyrin (marker of metal exposure) in the urine of children with autism.

This study was designed to see if porphyrin levels are higher in the urine of people with autism as compared to the urine of people without autism. Porphyrins can be found in the blood and they bind metal such as iron. Higher levels of certain porphyrins in the urine may suggest that the person has been exposed to mercury or other heavy metals. The study looked at patients with autism who went to the Genetic Centers of America for testing. The study found that people with autism had higher levels of the porphyrins that may signal mercury exposure. The authors tested the urine in two labs and found the results to be the same in both labs.


Clinical Toxicology, by Soden, SE, Lowry J. A., Garrison CB, and Wasserman GS, published in 2007, summarized Aug 3, 2007

Chelation therapy does not bring out higher levels of metals from the bodies of children with autism than it does from the bodies of other children.

This study was designed to see if children with autism have higher body burdens of heavy metals (arsenic, cadmium, lead, and mercury) than other children. If the heavy metals were present in children with autism then it might be helpful to get rid of them through chelation therapy. The authors note that there are no standards for how much heavy metals come out in the urine of "normal" children when the children were provoked by DMSA (chelation therapy). Standards do exist for the amount of heavy metals that can be found in the urine of "normal" children. The authors were not able to find any excess heavy metals in autistic children (standard urine and DMSA provoked urine).


Am J Clin Nutr., by Eritsland, J., published in 2000, summarized Nov 14, 2006

This article presents an overview of the side effects of supplementation with essential fatty acids (EFAs), and concludes that there is a very low risk of significant side effects. The author cautions, however, that distilled and purified EFAs should be used for supplementation.

The author reviews the research showing that EFAs, especially omega-3 fatty acids, have had mostly positive health impacts on cholesterol, immune function, and cancerous tumors. There have been a few studies showing negative effects of EFA supplementation. Most of these studies, however, have been with omega-6 fatty acids as opposed to omega-3 fatty acids. The author notes that increasing the dietary intake of EFAs should be done at the same time that saturated fats in the diet (found in meat and dairy products) are decreased. This way, weight gain will be prevented because the total fat intake is constant. Further, the author notes that EFA supplements can be contaminated with toxins, including mercury and pesticides. Therefore, supplements that are purified and distilled to remove these toxins should be used. The author also suggests that omega-6 fatty acids should be, at most, 10% of the daily intake of calories.


The National Institute of Mental Health (NIMH) had planned a study on the effects of chelation therapy on children with autism. Chelation therapy purports to pull toxic metals such as mercury from children. While some parents claim to have found chelation therapy helpful in reducing symptoms of autism, the NIMH found that there was no strong medical science to back up the parent claims. The NIMH was also concerned that the drug used for chelation (DMSA) was too risky for use with children. The NIMH therefore cancelled the chelation study.

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Please comment on this autism topic.

Denial?

Oct 25, 2006 by Anonymous

I wondered how I could miss the signs?  I had two boys and they were all close in age. My oldest was three when Katie was born. Was I too busy to notice....maybe.

 

I don't remember talking to her much as a baby, she was just in tow while I cared for the others....maybe I didn't play enough games with her.....I quickly looked at past albums and some videos. She smiled and made eye contact....oh, there we were are all giggling together on the floor. There she is in her footsie pajamas at the gate watching me in the kitchen....

 

No, she wasn't ignored, as a matter of fact she was mommy's girl. She was such a good baby, would watch TV quietly or play with a set of crayons while I cleaned the house. She carried a blanket around and did this funny thing, she'd run it through her fingers and sometimes her toes. She's line up her crayons but would not color with them. She loved the teletubby figurines, but really just lined them up as well. And she loved to sit in boxes. Oh yea, and when we were outside, she'd lay on the ground and look up, I figured she was just taking it all in.

 

I can't even bear to ask friends if they ever noticed or had concerns. What could they have said...she was still a toddler.

 

OH, and the pediatrician. Wonderful man, but I hear this happens often..... I mention she's not talking or waving hi...he suggests to just give it time. Was he right? Sure he could have been, how many kids have burst of development making up for delays....lots....but a few more questions during our visit and he would have seen she may have had traits that might have suggested autismAutism just began exploding up here at the time, I know it wasn't on his radar.

 

I had no time to beat myself up trying to figure out the why's. Truth is, we diagnosed her early enough. Was it shots, was it diet or genetics...who cares, just gotta fix it. Now, as a precaution,  I don't get her combined MMR vaccines, we will do it separately. And flu shot...they have mercury free now....but you have to ask. Is it the Mercury, don't know, but know Mercury isn't good for you and I don't want to risk it.

 

Until Katie was nearly 3 she woke up nightly because of gas. During the same time we found out about the autism we did a lower GI, perhaps that would be it, and then we could fix it. The scope was clean, her intestines a beautiful and perfect pink (I couldn't believe he showed me the pictures). But, even still, we tried the Gluten-Casein free diet...which is very hard, but to no avail. She just grew out of it. But I know many kids that have similar issues and respond to the diet....I feel it's better to explore all options, just in case you hit the nail on the head!

 

It wasn't about chasing causes, but really trying to eliminate them. The only thing I didn't do was test for fragile X or do an MRI. She really didn't show anything that suggested either was appropriate. When I asked the doctor what we might do differently if she had fragile X, she said nothing. I knew a mother of children with fragile X....Autism was fine for me right now.


Biomedical Treatments

Oct 25, 2006 by Anonymous

My daughter has improved enormously on a specific protocol of supplements, detoxification, and gf/cf, soy free, glutamate free, low sugar diet. It is not idiopathic as she regressed after 165 mcg of thimerosal. She is now being treated for toxic encephalopathy, gut dysbiosis, an inability to excrete heavy metals, immune dysfunction, and food intolerances.

I see nothing on this site about many autistic children having immune and gut dysfunction, nor any studies about inflammation at all.

Autism: A Novel Form of Mercury Poisoning.
Medical Hypothesis, 2001.
Sallie Bernard, Albert Enyati, Lynn Redwood, RN, Teresa Binstock, PhD.

Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal.
Environmental Health Perspectives, Aug 2005.

Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors.
Neurotoxicology, Jan 2005.
S. Jill James, PhD [University of Arkansas].

Large Brains in Autism: The Challenge of Pervasive Abnormality.
The Neuroscientist, Volume 11, Number 5, 2005.
Martha Herbert, MD, PhD [Harvard University].

Neurotoxic Effects of Postnatal Thimerosal are Mouse Strain Dependent.
Molecular Psychiatry, Sep 2004.
Mady Hornig, MD [Columbia University].

Activation of Methionine Synthase by Insulin-like Growth Factor-1 and Dopamine: a Target for Neurodevelopmental Toxins and Thimerosal.
Molecular Psychiatry, July 2004.
Richard C. Deth, PhD [Northeastern University].

Neuroglial Activation and Neuroinflammation in the Brain of Patients with Autism.
Annals of Neurology, Feb 2005.
Diana L. Vargas, MD [Johns Hopkins University].

Reduced Levels of Mercury in First Baby Haircuts of Autistic Children
International Journal of Toxicology
Dr. Amy S. Holmes, Mark F. Blaxill, Boyd E. Haley, Ph.D.
March 14, 2003

Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: Their Relationship to Gastrointestinal Symptoms and Dietary Intervention.
Neuropsychobiology, 2005.
Harumi Jyonouchi, MD [New Jersey Medical School].

http://www.autismwebsite.com/ari/index.htm

 

 



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