Risperidone therapy may cause problems with growth and development in some children.
The purpose of this study was to see if risperidone treatment causes increases in the hormone prolactin. Certain children (CYP2D6 ultrarapid metabolizers) process risperidone differently and respond with higher levels of prolactin. The more risperidone the children are given, the higher the level of prolactin they make. At the end of eight weeks, these sensitive children had prolactin levels that were four-fold higher than untreated children. About 10% of children getting risperidone treatment have levels of prolactin that are considered unsafe.









Please comment on this autism topic.
Glass half empty or half full?...
Jun 21, 2009 by AnonymousThere are times in your life when uncertainty can make you doubt yourself. Times when it is hard to tell whether your glass is half empty or half full. Perhaps you ran into someone, an old classmate, whose career path has taken them places you only dream about. Perhaps you ran into an old friend who shared with you some accomplishment their child has achieved, or some possession that you cannot possibly realistically hope to own. There are many times in our lives when someone else’s good fortune will make us question ourselves. I guess that in itself is just human nature and I am human…ok, wait…didn’t I promise to get off this soapbox last week? Yes, we know I am human. Yes, we have already covered the I felt guilt and then vowed to make a difference declaration. And yes, yes..yes we already touched on the I am fortunate to have a child as beautiful, healthy and special as Joshua even though it involves a lot of work, time and energy. Gotcha. So since I don’t have a lot of time to expound on my virtues as a tireless dedicated ASD mom and I am sure you’re bored by now let’s just get to it. Straight, no chaser.
Last week was a crappy week. Maybe it had something to do with the nonstop rain, my over zealous self-medicating with the demon caffeine or maybe it was because I had looked at my once bouncy cheeked little boy and saw a young man standing nearly eye to eye with me and felt the beginnings of a panic attack coming on. Realization was not only hitting home, it was kicking my ass. Not only was my son facing the oncoming challenges of puberty, making friends, girls… (Ok, putting paper bag over mouth and nose and breathing deeply and slowly) but now my shield was gone as well. The reason why I could not go out with friends, join a specific social outing or go back to school to complete my degree. This realization came with the speed and impact of a skillfully placed combination of a prize fight. One minute I was feeling down about my life, next I was talking to another parent on Facebook (do not sit there and act as if I am the only Facebook addict out there) whom I had not seen since our sons were in kindergarten together. While I will not talk about her son’s condition here, needless to say after inquiring about him I felt like I had no right to complain though she admonished my saying so and said in her own kind hearted and generous way that as parents we have the right to complain and should not feel bad about it, nor should I pity her. I get tired of the things I struggle with; school, insurance issues, his difficulty with making friends. And then I am faced with the sobering fact that while I may have had to fight for services in school and through my insurance company there are those who cannot get an IEP, or who have no insurance or availability of services.
So, in short you may ask have I been humbled this week…maybe not the best word. Just a week when I saw my glass as half full as opposed to half empty and for once appreciated the glass more than the contents.
Essential Fatty Acids
Sep 24, 2006 by AnonymousEssential Fatty Acids
I could go on and on about essential fatty acids (EFAs). They are important. They are found in breast milk. Only recently are they being put in formula and only in the more expensive lipil formula. They are similar to the cod liver oil that our parents may have given us. There are plant sources of EFAs (i.e. flax) and animal sources (i.e. fish). Animal sources appear to be better absorbed and more effective than plant sources. There is a good and well thought out article on EFA's that can be found at PWS Playroom (http://www.pwsplayroom.com/efa.htm ).
These unsaturated fatty acids are easily used by your body to form the brain and the lipid layer around cells. Saturated fats (like butter) compete with unsaturated fats. There is some talk that ingestion of EFAs contributes to brain formation and intelligence. Have you heard about breast fed babies being smarter? If it is true, it is likely due to EFAs. Have you heard of fish being brain food? If this is true it is likely due to EFA's.
Check out the Cherab Foundation on EFAs (http://www.cherab.org/information/dietaryeffects/efabasics.html ). There is a lot of anecdotal evidence about fatty acids and language development. I found this story persuasive.
Finally, there is the role of these EFA's in metabolism. I haven't seen much discussion about this. I would welcome anyone's opinion as this is a stretch for me. But, there are a group of receptors called PPAR. They bind fatty acids and they are involved in numerous diseases including diabetes. Saturated fatty acids appear to bind them and initiate an inflammatory response that can have many bad downstream effects, such as heart disease. Unsaturated fatty acids compete for these receptors and have an anti-inflammatory effect. I am mulling this over...
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Sources
Nordic Naturals ProEFA. It can be found on http://www.speechville.com. You can order through the speechville site -- I know Kirkman labs and http://www.omega-direct.com handle this type. Other parents use the Natural Factors Rich Old Bend for Kid.
I have now switched to the Ultimate Omega formula. I am not convinced that we need more Omega-6's (present in the ProEFA blend) and would rather just supplement with the Omega-3's.
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Working them into your Diet
There is an interesting book called the Omega Diet that talks about oils. In my opinion, the book is a bit extreme, but makes really good points. I think that a diet high in flax oils and fish oils is good for most everyone.
I think that if you get into the groove it won't be so hard to incorporate. Maybe it will "work" and maybe it won't but probably you will all be healthier. There are many places to work in flax oil. There is a type of yummy bread made by Natural Ovens that has high levels of flax oils. They also make great (but expensive) snack bars. Plus, there are great frozen waffles with flax oil.
Fish can be eaten for fish oil and fish oil is pretty easy to take in capsule form. My whole family takes it. We call it "smart medicine."
The Omega Diet also mentions walnut oil and canola oil. I make my own salad dressings (oil and vinegar and spice) and switched from olive oil to walnut oil. It was pretty easy and tasty. I don't really bake, but keep thinking that bran muffins or banana nut bread made with walnut oil would probably be pretty tasty.
I am also a big honey person. When my kids want something sweet, I give them a teaspoonful of honey. They like it. Local honey is best if you can get it.
Also, this year we made the switch from regular potatoes to sweet potatoes. I am not sure what your guy would say about sweet potatoes, but they suit us well. It seems that you could do most anything with them that you could with real potatoes. Plus, they have the added benefit that you can add walnuts (and walnut oil??) and cinnamon and honey to them and call them dessert. :)
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Research
Nutr Health. 2004;18(1):3-27. Related Articles, Links
From superior adaptation and function to brain dysfunction--the neglect of epigenetic factors.
Saugstad LF.
Oslo Centre for Molecular Biology and Neuroscience, Institute for Basic Medical Sciences, University of Oslo, Norway.
With optimal pregnancy conditions (natural, enriched diet which includes fish) African (Digo) infants are 3-4 weeks ahead of European/American infants in sensorimotor terms at birth, and during the first year. Infants of semi-aquatic sea-gypsies swim before they walk, and have superior visual acuity compared with us. With adverse pregnancy behaviour (fear of fat, a trend to dieting), neglecting the need for brain fat to secure normal brain development and function, we run a risk of dysfunction--death. Sudden Infant Death Syndrome victims have depressed birth weight, lower levels of marine fat in brainstem than controls, and >80 suffer multiple hypoxic episodes prior to death. Depressed birth weight (more than 10% below mean) is seen in learning and behaviour disorders, and a trend towards weights of less than 3kg is increasing, which supports a rise in antenatal sub optimality. Given marine fat deficiency in pregnancy and infancy, neurons starved for fuel could delay myelination and maturation in the latest developed Frontal Lobes. The phylogenetic oldest Lateral Frontal Lobe System (feed-back mechanism etc.) derived from olfactory bulb-amygdala, which crosses in Anterior Commisure is probably spared, while the Medial Frontal Lobe System derived from Hippocampus-Cingulum and crosses in Corpus Callosum (delayed response task) is most likely affected. The rise in infantile autism (intact vision and hearing) with deficit in delayed response task only, could suggest a deficit in the Medial Frontal Lobe System. The human species is unique; 70% of total energy to the foetus goes to development of the brain, which mainly consists of marine fat. It undergoes pervasive regressive events, before birth, in infancy and at puberty. Minimal retraction of neuronal arborisation is advantageous. Attributable to adverse pregnancy childrearing practice, excessive retraction is likely prenatally and in infancy. Pubertal age affects the fundamental property of nervous tissue, excitability: excessive excitatory drive is seen in early, and a deficiency in late puberty. It is postulated that with adequate marine fat, there is probably no risk of psychopathology at the extremes, whereas a deficiency could lead to paroxysmal (subcortical) dysfunction in early puberty, and breakdown of cortical circuitry and cognitive dysfunctions in late puberty. The post-pubertal psychoses, schizophrenia and manic-depressive psychosis at the extremes of the pubertal age continuum, with contrasting excitability and biological treatment, are probably the result of continuous dietary deficiency, which has inactivated the expression of genes for myelin development and oligodendrocyte-related genes in their production of myelin. The beneficial effect of marine fat in both disorders, in other CNS disorders as well as in developmental dyslexia (DD) and ADHD among others, supports our usual diet is persistently deficient. We have neglected the similarity of our great brain to other mammals, and our marine heritage. Given the amount of marine fat needed to secure normal brain development and function is not known, nor the present dietary level, it seems unduly conjectural to postulate that a dietary deficiency in marine fat is causing brain dysfunction and death. However, all observations point in the same direction: our diet focusing on protein mainly, is deficient, the deficiency is most pronounced in maternal nutrition and in infancy.
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