Omega-3 fatty acid supplementation reduced impulsive behaviors in one strain of rats, and increased seizures in another strain of rats; some of these behaviors may be found in children with autism or autism spectrum disorders (ASD).
Rat strains are rats that are bred to each other so that they all have the same genes. Omega-3 fatty acid supplements were given to two rat strains in this study. One rat strain (Fast rats) has hyperactivity, learning problems, impulsive behaviors, and increased chance of seizures. Another strain (Slow rats) has few seizures and does not have the behavioral problems that the Fast rats have. The Fast rats had less impulsive behaviors when they had omega-3 therapy, but they have the same seizure sensitivity. The Slow rats’ behavior didn’t change, but they had more seizures when they had omega-3 therapy. The authors said that omega-3 therapy may have different effects in different people, and urged caution when using the therapy.









Please comment on this autism topic.
re: Guanfacine
Feb 15, 2012 by AnonymousMy son is 8 years old, diagnosed with autism, seizure disorder and vocal and motor tics. We have decided to put him on medication. His attention span is zero. We tried Ritalin, but it backfired. We are now trying guanfacine. It has been a few days at 1/2 mg twice a day. I have seen moderate improvement in his hyperactivity and tics. Last night, about 45 minutes after his dose, he became very sedated. More than I care for. Do these side effects become more pronounced or less after he gets used to the drug? It has been a very difficult decision to put him on medication. But at this point, it's either him or I. :(
Neurofeedback
Dec 28, 2007 by Anonymouswww.neurofeedback.org
What is Neurofeedback? (taken with permission from http://www.thebrainlabs.com/neurofeedback.shtml)
Neurofeedback uses sophisticated computer technology to train the brain. While there are different forms of neurofeedback (as discussed below), the most traditional form is known as EEG Biofeedback. In EEG Biofeedback, a child plays video/computer games with his/her brainwaves. During a typical session, EEG electrodes are placed on the scalp and/or ear lobe(s). These sensors only measure a child's brainwaves; no electrical current enters the brain. The information/brainwaves that are read by these sensors are fed to a computer that converts this information into gamelike (pacman game) displays that include visual and auditory feedback. An example of a typical set up is displayed below in Figure 1.
Figure 1
As a child learns to control and improve upon their brainwave patterns, their game score increases and they progress. The only way to succeed at the games is for a child to improve their brain and how it functions. Further examples are included below, including the game computer that the client sees in Figure 2 and the therapist computer that monitors the clients brain wave patterns in Figure 3.
Figure 2
Figure 3
As this is done over various sessions, a child's brain improves and their symptoms or problems reduce. There is also every reason to believe that if this is done over a long enough period of time that the changes that occur will be enduring. In addition to its' long-lasting effects, the other major advantage is the lack of significant side effects.
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What can Neurofeedback help?
Given that this therapy helps people to control and change their brainwaves, EEG biofeedback can potentially help with any problems that can be influenced by brainwaves. This would include almost anything controlled by the brain including thinking abilities, motoric responses, behavioral, emotional, and social difficulties.
Table 1 shows the types of conditions/diagnoses for which Neurofeedback has been shown to be helpful. The number of research studies verifying its' impact is also presented.
Table 1
A simple review of the data in Table 1 shows that Neurofeedback is considered effective for some Seizure Disorders and Attention Deficit Hyperactivity Disorder. In fact, at least three research studies (Fuchs et al., 2003; Monastra et al., 2002; Rossiter & LaVaque, 1995) have now shown that EEG biofeedback is equivalent in its' effectiveness as compared to stimulant medications for the treatment of ADHD symptoms, but without the side effects and with a greater duration of lasting effects.
While Neurofeedback has also been shown to be effective for other conditions observed in children, such as Traumatic Brain Injury, there are clearly conditions in which much more work and research is needed. These would include Learning Disabilities, Stroke and especially Tourette's Syndrome and Autistic Disorders.
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What are the different types of Neurofeedback?
There are three major forms of Neurofeedback. These are:
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What is EEG Biofeedback?
Clearly, the most well known and first form of Neurofeedback is EEG Biofeedback. It was first discovered in the late 1960's and early 1970's that individuals could learn to control their own brain waves when provided feedback about them and that this information could be used to minimize or control seizures. It was later found that EEG Biofeedback could be used to treat Attention Deficit Hyperactivity Disorder and other developmental conditions or problems.
The typical EEG Biofeedback session has been described and shown above. Typically, EEG Biofeedback is done with three electrodes arranged in a monopolar pattern. This means that one electrodes is placed on the scalp at a clinically significant location and the other two are placed at relatively neutral sites (e.g., earlobes). With these electrodes in place various EEG frequencies are rewarded and others inhibited. This occurs via the visual and/or auditory feedback received, often via a computer screen and image. For example, it is common to reward low beta frequencies (often associated with focused, calm thought processes) and inhibit lower frequency ranges (delta, theta), which are often associated with distraction, fatigue, etc. When these conditions are met, for example, the pacman will move rapidly through a maze. Following similar processes, brainwave patterns are shaped over time toward a client's therapeutic improvement.
EEG biofeedback can be performed in a monopolar fashion at any of at least 19 electrode sites. Alternatively, some therapists chose to use bipolar montage or arrangement. In such a pattern, there are now two electrodes placed on the scalp and one on one ear. Now, brainwave patterns are shaped between theses two electrode sites or so it is theorized. Possible electrode placements and sites are expansive given that there are at least 19 locations and two electrode pairing combinations.
Lastly, there is an advanced form of EEG biofeedback referred to as coherence training. Coherence training is done with two separate channels of EEG (3 electrodes times 2 for a total of 6 electrodes). Each electrode grouping is arranged in a monopolar fashion. There are then two electrodes on each earlobe and two electrodes on the scalp. The purpose of coherence training is to facilitate "communication" between two specific brain regions.
EEG biofeedback conducted with either monopolar or bipolar setups seeks to focus on the amplitude or magnitude of various EEG frequencies, encouraging some and discouraging others. Monopolar arrangements seek such changes over one particular location, while bipolar setups seek changes between two sites (theoretically speaking). The training of specific locations and EEG frequencies then becomes of critical importance. EEG frequencies are described in cycles per second and reflect the speed of processing at a particular brain region. The following table is a representation of common frequency ranges, their names and associated features.
Typically, EEG biofeedback seeks to encourage some frequency ranges and discourage others. As a result, the neurofeedback therapist is left to choose the type of training, where on the brain to train and what frequency ranges to reward or inhibit. Discussed below are some issues related to these choices and approaches to neurofeedback.
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What is Stimulation-Driven EEG Biofeedback?
The two most popular forms of enhanced or stimulation-driven neurofeedback are LENS and the Roshi. LENS, or Low Energy Neurofeedback System, uses a very low power electromagnetic field to carry feedback to the person receiving it. This signal seeks to change this persons' brainwaves in subtle ways. The goal is often to alter to dominant brainwave frequency so as to make it more powerful. The result may be increased self-regulation and skills.
The Roshi is also an enhanced form of neurofeedback. In its' many incarnations, Roshi involved light stimulation that emulates a normally fluctuating EEG signal and its' many frequency variations. This tends to "push" the person more towards normalcy than they would be otherwise.
There is some evidence to suggest that these forms of enhanced neurofeedback can be helpful, especially in complex cases.
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What is Hemoencephalography?
Hemoencephalography or HEG refers to brain blood flow, its' measurement, and use as a neurofeedback application. This is a completely unique form of neurofeedback that is separate and different than EEG Biofeedback.
The originator of this technique, Hershel Toomim, developed a technology referred to as Near Infrared HEG or nirHEG. This measurement and biofeedback device is housed in a headband, which contains a light source and two optodes. Infrared lights are flickered alternating between 660 and 850 nm. The absorption of these lights, and a ratio of the same, received at the optodes is a calculation of cerebral oxygenation. This is used in the form of feedback to allow the client to enhance their brain's functions.
Another form of HEG has also been developed by Jeffrey Carmen. This form, entitled Passive Infrared HEG or pirHEG, uses an infrared lense that serves as a brain thermometer and measures temperature and inferred cerebral metabolism. This may also be used as a form of neurofeedback to aide in the enhancement and regulation of brain functions.
HEG is somewhat limited in that it doesn't see through hair. However, it has the advantage of being insensitive to artifacts such as muscle tension or eye blinks which may interfere with EEG biofeedback. As a result, HEG may be particularly useful of neurofeedback of frontal lobe or system dysfunction.
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What types of assessments can help Neurofeedback?
Now that we know there are various form of Neurofeedback that could be applied to many different problems and brain regions, how does one decide what to do and where? Believe it or not, there are some within the field that believe that all people can be treated the same way or with the same protocol. This is not our approach. In our clinical practice, we individually tailor and Neurofeedback protocol to an individual's particular problems or symptoms and, importantly, the identifiable regions of brain dysfunction that related to these symptoms.
The following is a possible list of ways in which Neurofeedback could be tailored for an individual:
Give me some credit!
Sep 5, 2007 by AnonymousFinally, the new school year has begun! And everyone reading this is going to laugh at me because I actually miss Thomas a tiny bit when he’s at school. If you read my blogs from May, there was a lot of apprehension and downright horror at the thought of three solid months with no Thomas-breaks.
The neurologist finally got back to me about the EEG, but not that Friday or Monday right after it. After I had left repeated messages inquiring about the results – the latter ones conveying a great deal of frustration and desperation – the doctor finally called back and did apologize for the delay. She mentioned that she really wanted to comb the results and it took longer than usual. Fine, I understand. Why couldn’t anybody call me to tell me that? Who knows? They know how to bill insurance companies. They know how to send bills to patients’ homes. They definitely know how to cash checks with lightning speed and efficiency, but there seems to be a problem with picking up the phone and calling a worried mother. Hmpf.
Anyway, the reason it took so long to call back had to do with an abnormal “spike” in the EEG. So I guess this is good, sort of…Thomas may have a seizure disorder, and we found something on the EEG, so it wasn’t a waste. I’m kind of worried about what this spike means, though. It was nothing so obvious that the doctor could diagnose epilepsy, but it was a tiny something. She also mentioned that she was going to call Thomas’ pediatrician, but after she told me that I wondered why. What are they discussing? If she wanted to simply let the pediatrician know about the EEG, then why wouldn’t she just send a letter? She’s actually going to call? Herself, in-person? So that’s been pressing my “worry” button. She asked about the Clonidine again and when I said that it still helps Thomas fall asleep but doesn’t keep him asleep, her exact words were, “Yeah, see? I think something else might be going on here.” But what?
To find out what, she has ordered a 24-hour in-patient video EEG for Thomas. She assured me that the EEG people would be calling. They never did. I finally called them and was informed that the video EEG machine was broken. Broken? Can’t someone fix it? Do they only have one of these machines? Then she said that there weren’t any appointments available until the end of September anyway. This sounds like an angry restaurant manager who doesn’t want your business telling you that they’re out of coffee just so you’ll leave. I don’t get it.
So this possible seizure disorder is apparently not life-threatening or very serious because surely the doctor would have known that the EEG machine was not working and would have sent the order to another hospital with working equipment. I just don’t know what to do now. How long am I supposed to wait for this stuff? These people at this particular hospital have never been good about calling me for any reason, so how long should I wait for them to let me know what’s going on? I’ll keep everyone posted. Right now, I’m so frustrated that I’m ready to march in there, demand Thomas’ chart and EEG results and go to another doctor. That may be what I end up doing.
So Thomas’ teacher called last week to set up the long-awaited and much-anticipated home visit. She is very nice (and young…it seems like every teacher and doctor I meet lately could be my age or younger) and Thomas seems to like her. Her aide came over too and colored with the kids while Miss Teacher and I chatted. Luckily, she didn’t have a long list of required supplies, just a few “must haves” and a list of “optional” things that would help out. I mentioned to the teacher that I hadn’t yet heard from the transportation center about when the bus would be by to pick up Thomas and she thought that was strange. She called me on Friday (as I was preparing the family for Labor Day Weekend out-of-town) and said that Thomas’ file was empty. No bus request form, no emergency card, no permission slips – nothing that I filled out at the end of the last school year! I had to take the kids and go into school and fill everything out again, but the bad part is that it takes the bus at least one week to begin picking up a new student. So I’ve been taking Thomas to and from school these last two days and will have to transition him to bus service when SOMEONE calls me SOMETIME to tell me when they’ll begin picking up Thomas. So if it wasn’t for Thomas’ inquisitive and diligent teacher (who also found that the school had lost the papers for three other students in her class – AND I’ve met several other parents who have the same problem) we would have been waiting for the bus yesterday morning and it would never have come.
Why, why can’t anyone call me? Doctors and schools have our home phone number, my cell phone number, my husband’s office number, his cell number, my parent’s phone number, their cell numbers, my mother-in-law’s phone numbers and my e-mail address. So many ways to get in touch with me, but nobody seems to think it’s necessary. Nobody (except the teacher – thank God for her) even thinks it might be a nice thing to do to keep me informed. And I hate having to call and harass people, but you know what? I guess that’s just the way it is. Information will not be forthcoming, so I have to badger people until I know what I need to know. I’m so angry about this blatant and frankly rude lack of communication I could just scream. You pick up the phone, dial eleven numbers and tell someone something. Is that really so hard? Is it really so much to ask? Clearly, it is.
On a not-frustrated note, Thomas’ first two days of school have been great! He’s been telling me so much about what he did during the day. Today on his sheet, the “housekeeping” activity was circled, which blew me away. Thomas, pottering in the kitchen? Only if it means sprinkling a bag of flour over his head! But he was apparently doing some pretend cooking in the little classroom kitchenette! I asked him what he cooked and he said, “I cooked some little burgers.” I thought that was so cool! During his bath tonight, I asked him if he sang any songs and he said that he didn’t, but then he said, “Oh yeah. ‘Open and shut, open and shut, the doors on the bus go open and shut, all through the town!’” It’s typical that he should pick that particular verse, since he is so OCD about doors. Earlier in the day, he had mentioned that a classmate was “driving the bus,” which made no sense, but I put it together with the information garnered from the bathtub conversation and concluded that they must have been play-acting the song. I was delighted! I remember a year and a half ago, when he first started preschool. I would ask him about his day and he was completely silent. He would look out the window of the car and I would glance back at him in the rearview mirror and see that he was paying no attention to my questions.
We were at the cottage this weekend. Thomas, if you can believe it, went swimming in the lake! We were standing on the pier on Saturday and there were some other kids on the pier next door, getting ready for a boat ride. Thomas asked, “What are those kids doing?” I said, “I think they’re going on a boat ride and they’re going swimming.” Thomas stood there for a second and then said, “Mommy, get in the water with me.” I said something completely weird like, “What, this water?” indicating the water near the shoreline. He climbed right into the water and began splashing. After a minute, it became clear that our swimsuits were needed, so we changed and Hayley wanted to join us, so the kids spend a good two hours splashing in the water! Thomas kept saying, “See, Mommy? I’m not afraid anymore!” as he rolled around on his back in the water and thoroughly enjoyed the whole thing. We were and still are completely shocked by this turn-around, but also overjoyed! I just couldn’t believe it. We’re thrilled!
Everyone in our families has been talking about how great Thomas is doing and we know that he is doing well, but people say things like, “See? See how he’s playing with those kids? That’s great!” and “See how much he’s talking? He’s doing so well!” and “Wow! He’s in the water! That’s amazing!” Jonathan and I take these comments with a bit of an unsavory attitude because we’re the ones who had to teach these things to him. Nobody gets that. Everyone thinks that Thomas is doing these things of his own natural instinct. He’s not; we have urged him repeatedly to talk to other kids, play with other kids, do what the other kids are doing. It’s only been after repeated discussions about the lake water and watching other kids swimming that Thomas came to the decision that there was nothing to be afraid of. We’ve had to teach him so many things that come naturally to Hayley and other “typical” kids and nobody seems to understand that. My mother-in-law was saying to me, “Wow, Jen! He’s playing with those other kids!” I said, “Yeah! Playing with other kids, swimming in the lake – he’s cured!” We laughed about that, but these things have only come after so much hard work and talking to Thomas until we’re out of breath and showing him and guiding him and teaching him until we’re exhausted. We just want a little credit for filling in some of the holes that autism has punched in our son’s brain.
Keep those diagnoses comin'!
Jul 26, 2007 by AnonymousLots has happened since my last blog. My grandmother’s birthday party was a complete surprise to her, even though I had my doubts. How do you keep fifty family members from accidentally spilling the beans? Somehow, though, it came off without a hitch. The only problem we had was that Thomas and Jonathan missed the surprise because Thomas was concerned with the fact that we had left our car on the next block. He kept wandering over there and Jonathan had to follow. Once the surprise was over, I moved the car to our usual Uncle Tom’s House parking spot and Thomas settled down. Again, the kids swam until it was dark. We had a really good time and Grandma was very surprised.
We visited the neurologist again last week and we chatted for a while about Thomas’ nighttime antics. The Clonidine is still not keeping him asleep like the doctor thought it would, so we talked about exactly what he does when he gets up in the night. After thinking for a moment, the neurologist asked that we bring Thomas for an EEG (electroencephalogram), when they put stickers and wires on his head while he’s sleeping and wait for something (a seizure) to happen. The doctor was concerned, after I told her about how Thomas wet his bed several times in one night and seems to have a “lights are on but no one’s home” look about him when he wakes, that he is having seizures. I’ve been asked many times before if Thomas has seizures, but I wrongly assumed that seizure behavior is passing out and writhing on the floor for a few seconds. After educating myself with the pamphlet entitled “Understanding Epilepsy” that the doctor provided, I’ve learned that seizures can be a blank stare, slight twitching, a single severe muscle spasm and other things I had never thought of as “seizure behavior”. Once she gave me that particular piece of literature, a red flag was raised: So Thomas could have epilepsy ON TOP OF autism? Swell! Let’s keep those diagnoses comin’! By the way, I gave the neurologist the studies on Namenda/Memantine, and she remains unconvinced that there is enough information available on the drug for use in children with ASD. I’m not sure what to do next…how much money would I need to bribe her, I wonder? Maybe I should turn these requests into a singing telegram. I can bring balloons and my tap shoes next time and wear an ape suit.
Thomas may not have epilepsy, in fact; the doctor wants the EEG just to make sure that epileptic seizures are not to blame for the sleeping problems. So if Thomas has the EEG and it’s abnormal, then we come back for a consultation with the neuro. If the EEG is normal, then she wants him to do a sleep study. I’m so excited for these tests that I can’t even express it in words!
Not.
The preparation for an EEG is horrific. I mean, if I was the one who had to have the test, it would be no big deal. The fact that I have to prepare a four-and-a-half year-old autistic child for it absolutely curls my hair. The whole idea of this test is to get a look at the brain waves while Thomas is sleeping, so sleep deprivation is key to the success of the EEG. The person on the phone instructed me to put Thomas down for bed at the normal time and then wake him at 1:30 a.m. (in the morning, in case you missed the “a.m.”) and keep him awake until the test which is scheduled for 10:45 a.m. Trying to get him to stay awake in the car on the way there is going to be a scream! Jonathan is taking that day off work so that one of us can drive the car while the other entertains Thomas. If we can just get him to stay up all that time, the test should go fairly smoothly. Of course, I’m going to need someone to keep me awake all those hours. Everyone’s sleep schedule is going to be completely screwed up. I already know exactly what’s going to happen. Our whole family is going to be up at 1:30 a.m. like a bunch of vampires.
The main thing is that I really don’t know what to hope for in all of this. Like, what are the best-case and worst-case scenarios? How can the best-case be that Thomas has epilepsy? That’s just silly. Then again, if he doesn’t have epilepsy, we have to dig even further and do a sleep study (again, my hair is curling just thinking about that) and continue to grab at straws. Then, they may want to do an all-day EEG where I have to get Thomas to walk around like Frankenstein for twenty-four hours with a mobile EEG pack around his waist and wires sticking out of his head. What should I hope for? This may sound horrible, but I would be fine with it if Thomas has epilepsy. My best friend has epilepsy and she’s completely normal with her daily medication. If epilepsy would help us pinpoint Thomas’ sleeping problems, fine. So we’re beginning another journey to possible diagnosis, and possible nothing. This whole thing may lead us to no answers at all. “Yeah, your son has sleep problems. We can’t figure out why. That’ll be nine zillion dollars. Have a nice day!”
Yeah, yeah, I’ll try to stay optimistic. The EEG is scheduled for August 16th.
Otherwise Thomas has been pretty good. We’ve gotten Hayley almost completely potty-trained, so we’re done with diapers! She sometimes doesn’t make it through the night without wetting the bed, so we’re putting her in a diaper at bedtime (okay, so not “done-done” with diapers, but pretty close). In the morning, bless her little heart, she gets up and goes to the bathroom all by herself without waking me up! She’s doing a great job (even with #2!) and we’re so proud of her. Thomas is obsessed with our cars (again or still?) and demands that I pull our truck in the garage in the morning so he can look at it and get in and out of it. He enjoys it and it’s not hurting anyone, so I let him do it. He has been talking about how he wants to be a racecar driver, which is cute. Today he wanted us to go to the “car store” and buy a Toyota Highlander like the one my dad drives. I told him that I don’t have enough money to buy one and that they cost around forty thousand dollars. Thomas remained firm in his desire despite my silly lack-of-funds problem. He’ll just have to wait for Grandpa to work on our boring old Suburban again so we can borrow his car.