Autism Therapy: stimulant

definition of stimulant: not yet defined.

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Journal of Clinical Psychopharmacology, by Gerhard, T., Chavez B., Olfson M., and Crystal S., published in 2009, summarized Jun 17, 2010

Many drugs are prescribed to help manage the symptoms of autism and yet very few studies have been done to demonstrate that these medications are helpful.

This article describes the use of drug therapy in the U.S. for youth with autism. Recently, there has been a large increase in the use of brain drugs (psychotropic medications) to treat young people with autism. This may be due to the fact that more people know about autism. It may also be due to the presence of new drugs such as atypical antipsychotics and newer stimulants. There are no guidelines to help doctors know how to prescribe brain drugs to help children with autism.


Annals of the American Psychotherapy Association, by Bhagar, HA, and Schmetzer AD, published in 2008, summarized Nov 25, 2009

Children with autism may benefit from behavioral therapies and medications.

The common approach to therapy for children with autism is a combination of behavioral therapy and medication (drug therapy). One study reported that 70% of children with autism 8 years old and older receive some form of medication. Common types of medication include antidepressants, stimulants, and antipsychotics.


Child Care Health Dev., by Sandler, AD, and Blodfish JW, published in 2008, summarized Sep 17, 2009

A placebo effect may allow doctors to lower the prescribed doses of drug therapy for behavioral disorders like ADHD and autism.

This pilot study looked at whether children who knowingly took placebo together with their regular drug therapy could lower their drug dose. In the study, there were 26 children (7-15 years old) with attention-deficit hyperactivity disorder (ADHD). The researchers wanted to find out if children could use lower drug therapy doses with this treatment. They told the parents and the children that they were taking placebo with their medications. The children were taking "stimulant drugs" (not named in the article) for their ADHD. When the drug dose was cut in half and placebo added, behaviors remained the same for 8 out of 26 patients. In other words, the children behaved as if they were taking a full dose of drug. The authors think that this placebo effect might be helpful for lowering doses of medication for children.


Int J Disabil Hum Dev, by Anywanwu, EC, published in 2008, summarized Jul 18, 2008

Behavior therapy such as applied behavior analysis (ABA) may be a better choice than drug therapy for children with autism.

In this paper the author reviewed the use of drug therapy to treat autism and compared the use of medications to the use of other autism therapies. Doctors provide many different types of medications to people with autism: antidepressants, stimulants, antipsychotics, alpha agonists, and anticonvulsants. The author states that 50% of adults and children in with autism in the U.S. are prescribed one or more of these types of medications. Drug therapy may relieve some of the symptoms that come with autism, but often the drug therapies bring with them side effects. The author concludes that drug therapy may not be the best therapy choice for people with autism.


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I'm on-board...by myself

Jan 23, 2009 by dankohn

Winter stinks. I'm serious. I've had it up to here, literally, with the snow. And I can't stand the cold. The older I get, the harder it is for me to just breathe outside in sub-zero temperatures. The Norman Rockwell imagery is only enticing up to and including Christmas. After that, those images get old. As winter goes on, they become a source of contempt and scorn. My sister lives in California and she laughs and laughs when she says, "Gee, it sure is cold here. It got down to fifty degrees overnight!"

Strangely enough, the cold weather seems to affect the kids not at all. Last week, the kids had an unexpected five-day weekend. School was cancelled Thursday, Friday and Martin Luther King Jr. Day was Monday. A nice little mini-break during which we had NOTHING to do because we couldn't leave the house. Actually, the car did start on Thursday so I took the kids to Target. We wandered aimlessly before picking up Jonathan's blood pressure medications and then one of the wisest, most useful purchases I've ever made: a heated mattress pad. It's wonderful. It's like slipping into a hot tub in bed at night. I can't stand sheets made from anything other than at least 250 thread-count cotton, so flannel sheets are out. I need smooth, but the cotton ones get so cold. Ha - not anymore. Thanks for the gift card, Aunt Sally! We used it well.

Speaking of beds, Thomas is still playing musical beds at night. He is getting better, though. He will come in every other night or so. This morning, he did wait until after Jonathan got up for work to come into our bed. That's our little rule; they can't come in until Daddy gets up for work. Hayley disregards this rule entirely. She usually comes in around 1 a.m. (I think...) but she's such a good snuggler. If I'm still up when she comes in, I send her back to her bed. Lately, since we've been using this heated mattress pad, if I've got mine on (there are separate controls for each side of the bed) and Hayley's snuggled up against me, I wake up soaked with my own, and also some of Hayley's, sweat.

Thomas has been doing really well in school. Last Tuesday when I was in class, the teacher had each of the kids take a dry-erase board and a marker and sit on the floor and practice writing words. This seemed like something we could do at home, so I took a huge dry-erase board from an easel that nobody uses, cut it in half with a jigsaw, and now Thomas and I spend a few minutes every day writing what his teacher calls "popcorn" words; words that come up in conversation a lot. Words like can, today, we, him, she, it, etc. I also pick a really simple book from our shelf and try to get him to sound out words with me. Most of the time he is very reluctant and complains and whines about it. The fact is that he simply does not like to read or write. He might like to read if he learned how, but I don't think that writing will ever be his favorite thing to do. Hayley loves to do it mostly because she lives for praise from grown-ups. Thomas gets shy and anxious when Jonathan and I praise him for his efforts. We try to keep that kind of thing to a minimum, just saying, "Good, okay, what's the next word?" If we don't jump up and down and clap our hands and shout, he's okay. Hayley loves the jumping and clapping.

Today Thomas saw the occupational therapist. She came out to talk to me while the kids were getting their coats on. She mentioned how much improved Thomas is at writing his name. When we try to write it at home, Thomas makes such big letters or he starts writing in a spot that doesn't give him enough room to finish his whole name. The OT gave him a very long strip of paper today, so he was able to fit all the letters on it. He sometimes makes the letter "s" backwards, but she told me that they don't get concerned about that until second grade. He also needs to work on his lower-case "h" and "n" since they look very similar. Other than that, she said he's doing really well and she's noticed an improvement. Something I forgot to ask her was if she's noticed Thomas needing a lot more OT since after winter break, which has always been a hard time for him. Nobody has said anything and the extra OT minutes are built into his schedule this time of year, so if he needs it, he's getting it.

So far, we haven't noticed any side-effects from the Strattera. I don't know if it's really doing anything for him, but that's what we said about the Focalin until we took him off of it. It had been making a tremendous difference...along with a disconcerting facial tic. Jonathan works with a woman whose boyfriend's son is autistic with symptoms of ADHD. She said that this young man had developed an extremely pronounced facial tic while taking Ritalin or Focalin or something...one of the stimulants, anyway. She said that he was switched to Strattera too and hasn't had any tic problems and the medication seems to work for him. Thomas has been taking it for just over two weeks. The doctor said it needs to ramp up in his system for about four weeks before we might notice a difference, so I'm counting the days. I'm also supposed to call her around February 7 to let her know how things are going. She may decide to raise the dose from 10 mg to 18 mg. The lower dose of Focalin didn't produce a facial tic, but the higher one did. We'll see. At least we don't get bored, having to constantly observe our child for signs of one of the millions of side-effects of these meds.

I had the chance to speak to an old college friend of mine that I got in touch with on Facebook earlier this month. It just so happens that his own son was diagnosed with autism as well. He and his wife are 100% sure it was the 18 month MMR shot because he had been doing fine; meeting milestones and developing normally until he had that shot. He lost all of his words over the course of the week following the shot and was a completely different kid one week after the shot. I know that there are a lot of people out there who have dismissed vaccines as a cause of autism (mostly doctors and drug companies, no?), but it's stories like this one from my friend that really make me wonder.

I'm starting to think that autism is not caused by one thing only. I think that vaccines could cause it, but I don't think that Thomas' autism was caused by a shot. He never "lost" words; he just never had any words to lose until he started speech therapy. I really wonder a lot about the flu shot I had in my third trimester with Thomas; my doctor told me to get one, so I did. I wonder if something funky happened with that. The other possibility is that Jonathan was working on a job site during the time Thomas was conceived and while I was pregnant. This site was known to have heavy metals in the soil and Jonathan had to have blood tests before he started working there and after he finished the job to make sure he wasn't poisoned. I don't know if that kind of thing can get into sperm; it would seem that if it did, the sperm would be incapacitated and therefore unable to do its genetic job. Who knows? I'm not a doctor. But I do wonder if Jonathan went to work, put his dirty (heavy metals-laden) jeans and socks in the laundry basket, and then I handled those clothes, shaking them out occasionally and probably releasing all kinds of toxins in the air that I must have inhaled. It's my best guess at this point.

My friend with the autistic son pretty much considers his boy "recovered" due to their strict gluten and casein-free (GFCF) diet. I've really been wondering if we should try it. Of course, this is no time to be spending hundreds more per month on groceries, but I do wonder if Thomas would benefit from it. Jonathan does not want to do it, but purely for selfish reasons, I think. If one person in the house is GFCF, the whole family has to be. I must admit, it would be hard for us; I myself am a bread and pasta junkie, but if Thomas could "recover," my God - how could we not do it? I'm going to check out my buddy's wife's website, gfcfdoneeasy.com, and see if it really can be done easily. For as hard as it would be on Jonathan and I (I don't think Hayley would care much; she never eats that much anyway), it would hands-down be hardest on Thomas. I'll have to think about it a lot more, but I'm really beginning to think we should try it. If it doesn't work, it doesn't work and we can go back to our usual eating habits. But what if it does work? I've heard different statistics about it, saying that anywhere from 60% to 80% of autistic or special-needs kids benefit in some way from a GFCF diet.

The problem is, we all have to be on-board. Right now, I'm on this little board all by myself.


Let's go to the hop!

Jan 9, 2009 by dankohn

As is usual, Christmas and New Year’s have come and gone in the blink of an eye. Did I enjoy it? I can’t remember…it really was a blur. Actually, I noticed that I enjoyed the holiday season less than usual which breaks my heart. Being so worried about Jonathan’s job and money put a damper on things, but we made merry nevertheless. The kids had a great time opening presents and stuffing their faces with junk food from Christmas Eve all the way through Christmas night. Everyone was very generous as usual, especially Santa. Thomas loved his bicycle and actually was pleased to wear the helmet as he rode the bike around the living room, sending knick-knacks and cats flying, as I foresaw.

One shocker, however, was that the bike was not his favorite present. Mrs. Claus saw in Barnes & Noble one of those Klutz kits with a human skeleton and book in it. Mr. Claus was not enthusiastic about buying it, believing that young Thomas wouldn’t really care for it. Was Mr. Claus ever wrong! Thomas loves that skeleton so much that it is still in one piece and he puts it in its little display case every time he’s done playing with it! He also got a pop-up book about the human body which he really seems to get into.

Hayley has not yet shown an aptitude for any specific area of academia. She got the Barbie Overpriced Diamond Castle and several of the dolls that go along with and she was quite thrilled with that. Both of the kids got clothes from certain people, and those people know who they are, and I thank them most heartily.

I took the tree down on December 28, a full two days later than usual. It was also a forty-degree day so we went outside with the new bike while I took down the outside lights. The kids toys are getting smaller (and more expensive) so we didn’t immediately need the room in the house occupied by the tree. Thomas eventually conceded that the bicycle should live in the garage which was a huge win for me. We re-arranged Hayley’s room to accommodate Barbie’s new digs with little trouble and I just purged all of the old give-away stuff from the kids’ rooms. I’m going to start on the closets and dressers in all the rooms next.

New Year’s was a quiet affair. My sister, her new husband, and my other sister came over and we played games and tossed back a few. Very low-key and we didn’t have to find a babysitter since everyone came to us! That kind of New Year’s, with my sisters and brother-in-law is beginning to be a tradition because we did it last year too. I’d be happy if we did that kind of thing every New Year’s forever.

The rest of the holiday break went swiftly…It felt like it flew by. This past Tuesday, we saw Thomas’ neurologist for a check-up. We both lamented the bad luck that the Focalin, while immensely helpful for Thomas’ ADHD symptoms, also caused that disturbing facial tic. She has started him on Strattera which is for ADHD symptoms, but is not a stimulant like Ritalin or the others. It can still cause tics, but maybe it won’t because it works differently. He’s going to continue with the Clonidine as well because that happens to be an anti-tic medication in addition to all of the other things it can do. Strattera is a medication that “banks” or “ramps up” in your system, so it may be four to six weeks before we notice any improvements. Or tics. But I’m trying to stay optimistic. I told his service team at school that he is on this new medication and they should observe and report.

The first week back to school was great for Thomas, mostly because he spent all of break asking when he’d go back to school again. He really enjoys it, or he needs it; either way, he’s cool with school. My brother-in-law and his fiancée gave Thomas and Hayley their own little dry-erase boards for Christmas and I had a brainstorm yesterday as I was cleaning and de-crapitizing (I made that word up, but I bet you know what it means). I decided to draw a little picture schedule for Thomas on his board to help him get dressed in the morning. He has such a difficult time completing multi-step tasks. I cannot just tell him, “Go get dressed.” He has to have constant verbal cues about what to do next. So I drew little pictures for him on the board: taking off pajamas, putting on shirt, putting on pants and putting on socks and shoes. Here’s the problem: Thomas can’t read and I’m not a very good artist. So we have to kind of work on it together. The whole point eventually is for Thomas to not need the visual cues anymore and just get dressed when I ask him to. Hopefully, by springtime he’ll have it down. That’s a good goal, I think.

Today at school there was a sock-hop for all of the kids who didn’t have any “office referrals” (that’s “not being sent to the principal’s office” to you and me). Since kindergartners are generally never sent to the principal’s office, the whole class got to go and Thomas’ teacher said that she wished I had been there to see! He danced with a nice girl in his class (holding hands, even!) and he did the Bunny Hop with the other kids…he completely participated and even enjoyed himself a lot, it seemed. Actually, the girl that he was dancing with has been his “special friend” lately and the teacher has had to remind Thomas about personal space. This little girl is a sweetheart and very smart; she can already read, actually…but I thanked her for dancing with Thomas today.

So the weather here is crummy again. Those meteorologists should all be canned. The high here next Wednesday is zero. Zero degrees is the high. Honestly, if we can’t make the house payment or buy food, it’s not going to be because Jonathan was laid off! It’ll be because of the awful weather! At least there’s nothing you can do about the weather. Nobody’s to blame.

Hopefully, we’ll have a good few days sometime late next week (or next month…or never) to make a snowman and take the kids sledding. Thomas really loved sledding last year and I’d love to take him again. I’m still waiting for weather conditions to be right for taking them to school on a sled like a mush-dog.

For now, we’re holed-up in our little house, peering hopefully through the curtains every day looking for sunshine, crossing our fingers as the car sluggishly cranks and then barely catches on those coldest mornings, being thankful that we have heat and what we need to get by for now. Taking it one day at a time, I guess.


Neurofeedback

Dec 28, 2007 by Anonymous

www.neurofeedback.org

What is Neurofeedback? (taken with permission from http://www.thebrainlabs.com/neurofeedback.shtml)

Neurofeedback uses sophisticated computer technology to train the brain. While there are different forms of neurofeedback (as discussed below), the most traditional form is known as EEG Biofeedback. In EEG Biofeedback, a child plays video/computer games with his/her brainwaves. During a typical session, EEG electrodes are placed on the scalp and/or ear lobe(s). These sensors only measure a child's brainwaves; no electrical current enters the brain. The information/brainwaves that are read by these sensors are fed to a computer that converts this information into gamelike (pacman game) displays that include visual and auditory feedback. An example of a typical set up is displayed below in Figure 1.

Figure 1

As a child learns to control and improve upon their brainwave patterns, their game score increases and they progress. The only way to succeed at the games is for a child to improve their brain and how it functions. Further examples are included below, including the game computer that the client sees in Figure 2 and the therapist computer that monitors the clients brain wave patterns in Figure 3.

Figure 2
Figure 3

As this is done over various sessions, a child's brain improves and their symptoms or problems reduce. There is also every reason to believe that if this is done over a long enough period of time that the changes that occur will be enduring. In addition to its' long-lasting effects, the other major advantage is the lack of significant side effects.

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What can Neurofeedback help?

Given that this therapy helps people to control and change their brainwaves, EEG biofeedback can potentially help with any problems that can be influenced by brainwaves. This would include almost anything controlled by the brain including thinking abilities, motoric responses, behavioral, emotional, and social difficulties.

Table 1 shows the types of conditions/diagnoses for which Neurofeedback has been shown to be helpful. The number of research studies verifying its' impact is also presented.

Table 1

A simple review of the data in Table 1 shows that Neurofeedback is considered effective for some Seizure Disorders and Attention Deficit Hyperactivity Disorder. In fact, at least three research studies (Fuchs et al., 2003; Monastra et al., 2002; Rossiter & LaVaque, 1995) have now shown that EEG biofeedback is equivalent in its' effectiveness as compared to stimulant medications for the treatment of ADHD symptoms, but without the side effects and with a greater duration of lasting effects.

While Neurofeedback has also been shown to be effective for other conditions observed in children, such as Traumatic Brain Injury, there are clearly conditions in which much more work and research is needed. These would include Learning Disabilities, Stroke and especially Tourette's Syndrome and Autistic Disorders.

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What are the different types of Neurofeedback?

There are three major forms of Neurofeedback. These are:

  1. EEG Biofeedback (monopolar, bipolar, coherence training)
  2. Stimulation-Driven EEG Biofeedback (Roshi, LENS)
  3. Hemoencephalography (nirHEG, pirHEG)

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What is EEG Biofeedback?

Clearly, the most well known and first form of Neurofeedback is EEG Biofeedback. It was first discovered in the late 1960's and early 1970's that individuals could learn to control their own brain waves when provided feedback about them and that this information could be used to minimize or control seizures. It was later found that EEG Biofeedback could be used to treat Attention Deficit Hyperactivity Disorder and other developmental conditions or problems.

The typical EEG Biofeedback session has been described and shown above. Typically, EEG Biofeedback is done with three electrodes arranged in a monopolar pattern. This means that one electrodes is placed on the scalp at a clinically significant location and the other two are placed at relatively neutral sites (e.g., earlobes). With these electrodes in place various EEG frequencies are rewarded and others inhibited. This occurs via the visual and/or auditory feedback received, often via a computer screen and image. For example, it is common to reward low beta frequencies (often associated with focused, calm thought processes) and inhibit lower frequency ranges (delta, theta), which are often associated with distraction, fatigue, etc. When these conditions are met, for example, the pacman will move rapidly through a maze. Following similar processes, brainwave patterns are shaped over time toward a client's therapeutic improvement.

EEG biofeedback can be performed in a monopolar fashion at any of at least 19 electrode sites. Alternatively, some therapists chose to use bipolar montage or arrangement. In such a pattern, there are now two electrodes placed on the scalp and one on one ear. Now, brainwave patterns are shaped between theses two electrode sites or so it is theorized. Possible electrode placements and sites are expansive given that there are at least 19 locations and two electrode pairing combinations.

Lastly, there is an advanced form of EEG biofeedback referred to as coherence training. Coherence training is done with two separate channels of EEG (3 electrodes times 2 for a total of 6 electrodes). Each electrode grouping is arranged in a monopolar fashion. There are then two electrodes on each earlobe and two electrodes on the scalp. The purpose of coherence training is to facilitate "communication" between two specific brain regions.

EEG biofeedback conducted with either monopolar or bipolar setups seeks to focus on the amplitude or magnitude of various EEG frequencies, encouraging some and discouraging others. Monopolar arrangements seek such changes over one particular location, while bipolar setups seek changes between two sites (theoretically speaking). The training of specific locations and EEG frequencies then becomes of critical importance. EEG frequencies are described in cycles per second and reflect the speed of processing at a particular brain region. The following table is a representation of common frequency ranges, their names and associated features.

Typically, EEG biofeedback seeks to encourage some frequency ranges and discourage others. As a result, the neurofeedback therapist is left to choose the type of training, where on the brain to train and what frequency ranges to reward or inhibit. Discussed below are some issues related to these choices and approaches to neurofeedback.

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What is Stimulation-Driven EEG Biofeedback?

The two most popular forms of enhanced or stimulation-driven neurofeedback are LENS and the Roshi. LENS, or Low Energy Neurofeedback System, uses a very low power electromagnetic field to carry feedback to the person receiving it. This signal seeks to change this persons' brainwaves in subtle ways. The goal is often to alter to dominant brainwave frequency so as to make it more powerful. The result may be increased self-regulation and skills.

The Roshi is also an enhanced form of neurofeedback. In its' many incarnations, Roshi involved light stimulation that emulates a normally fluctuating EEG signal and its' many frequency variations. This tends to "push" the person more towards normalcy than they would be otherwise.

There is some evidence to suggest that these forms of enhanced neurofeedback can be helpful, especially in complex cases.

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What is Hemoencephalography?

Hemoencephalography or HEG refers to brain blood flow, its' measurement, and use as a neurofeedback application. This is a completely unique form of neurofeedback that is separate and different than EEG Biofeedback.

The originator of this technique, Hershel Toomim, developed a technology referred to as Near Infrared HEG or nirHEG. This measurement and biofeedback device is housed in a headband, which contains a light source and two optodes. Infrared lights are flickered alternating between 660 and 850 nm. The absorption of these lights, and a ratio of the same, received at the optodes is a calculation of cerebral oxygenation. This is used in the form of feedback to allow the client to enhance their brain's functions.

Another form of HEG has also been developed by Jeffrey Carmen. This form, entitled Passive Infrared HEG or pirHEG, uses an infrared lense that serves as a brain thermometer and measures temperature and inferred cerebral metabolism. This may also be used as a form of neurofeedback to aide in the enhancement and regulation of brain functions.

HEG is somewhat limited in that it doesn't see through hair. However, it has the advantage of being insensitive to artifacts such as muscle tension or eye blinks which may interfere with EEG biofeedback. As a result, HEG may be particularly useful of neurofeedback of frontal lobe or system dysfunction.

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What types of assessments can help Neurofeedback?

Now that we know there are various form of Neurofeedback that could be applied to many different problems and brain regions, how does one decide what to do and where? Believe it or not, there are some within the field that believe that all people can be treated the same way or with the same protocol. This is not our approach. In our clinical practice, we individually tailor and Neurofeedback protocol to an individual's particular problems or symptoms and, importantly, the identifiable regions of brain dysfunction that related to these symptoms.

The following is a possible list of ways in which Neurofeedback could be tailored for an individual:

  1. Based on symptom presentation with an understanding of brain regions that mediate these functions or skills.
  2. Protocols for particular problems or "tricks of the trade." For example, the most common protocol for ADHD is EEG biofeedback done over the top of brain (Cz, C4-C3) rewarding SMR and inhibiting theta and high beta activity.
  3. Using psychological assessment information such as parent ratings scales and tests of attention such as TOVA or IVA.
  4. Use of more complex neuropsychological tests to diagnose regions of brain dysfunction and treatment plan accordingly.
  5. Use of direct neurophysiological measurement to determine brain dysfunction and treatment plan accordingly. This is often done with something called a QEEG or Quantitative Encephalogram or EEG.


Please comment on stimulant or other autism therapy topics.

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