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Healing Thresholds Autism Therapy Topic Feed http://autism.healingthresholds.com/therapy/tenex-intuniv-guanfacine/feed en The Pharmacologic Treatment of Attention Deficit and Hyperactivity in Autism http://autism.healingthresholds.com/research/pharmacologic-treatment-attention-deficit-and-hyperactivity-autism <div id="biblio-node"><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.atitle=The+Pharmacologic+Treatment+of+Attention+Deficit+and+Hyperactivity+in+Autism&rft.title=Primary+Psychiatry&rft.date=2009&rft.volume=16&rft.issue=1&rft.spage=55&rft.epage=60&rft.aulast=Kolevzon&rft.auinit=A"></span><table> <tbody> <tr class="odd"><td class="biblio-row-title biblio-field-title-title">Title</td><td class="biblio-field-contents-title">The Pharmacologic Treatment of Attention Deficit and Hyperactivity in Autism</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-type">Publication Type</td><td class="biblio-field-contents-type">Journal Article</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-authors">Authors</td><td class="biblio-field-contents-authors"><a href="/research-index/author/1416">Kolevzon A</a></td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-secondary-title">Journal Title</td><td class="biblio-field-contents-secondary-title">Primary Psychiatry</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-year">Year of Publication</td><td class="biblio-field-contents-year">2009</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-volume">Volume</td><td class="biblio-field-contents-volume">16</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-issue">Issue</td><td class="biblio-field-contents-issue">1</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-pages">Pages</td><td class="biblio-field-contents-pages">55-60</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-url">URL for Abstract</td><td class="biblio-field-contents-url"><a href="http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=1955">http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=1955</a></td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-abst-e">Teaser</td><td class="biblio-field-contents-abst-e"> <p>Some medications may improve attention spans and decrease <a class="glossary-term" href="/therapy/hyperactivity"><cite title="definition of hyperactivity: A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a> in people with <a class="glossary-term" href="/therapy/autism"><cite title="definition of autism: Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>.</p> </td> </tr> <tr class="odd"><td valign="top">Full Text</td><td> <p>Some medications may improve attention spans and decrease <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a> in people with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>.<br><br>The author describes clinical trials of <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drug therapies</cite></a> in <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>. <a class="glossary-term" href="/therapy/ritalin-methylin-methylphenidate-hydrochloride"><cite title=" Ritalin®, Ritalin LA®, Methylin Oral®, or Methylin® are mild central nervous system stimulants that may be prescribed for people with autism to help reduce hyperactivity and repetitive movements. Methylphenidate is indicated for treatment of attention deficit disorder (ADD), attention-deficit/hyperactivity disorder (ADHD), and narcolepsy (falling asleep at the wrong times).">Methylphenidate</cite></a> and <a class="glossary-term" href="/therapy/strattera-atomoxetine-hydrochloride"><cite title=" This medication may be prescribed off-label for people with autism to help with hyperactivity, obsessions, and other behavior problems. Strattera® is usually prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). Strattera® works by changing the ways some neurons are turned on and off. One possible serious side effect is increased risk of suicidal thinking and behavior in children, adolescents, and young adults. The risk of this side effect needs to be weighed carefully with the clinical need. Families should be aware of the need for close observation of the child or adolescent taking this medication, and maintain communication with the doctor who prescribed it. ">atomoxetine</cite></a> are both used to treat <a class="glossary-term" href="/therapy/attention-deficit-hyperactivity-disorder-adhd"><cite title=" ADHD is a neurological disorder resulting in inattention, hyperactivity, and impulsivity. ADHD is not included in the autism spectrum disorders.">attention-deficit hyperactivity disorder (ADHD)</cite></a>. These <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drugs</cite></a> may also help treat <a class="glossary-term" href="/therapy/attention-deficit-hyperactivity-disorder-adhd"><cite title=" ADHD is a neurological disorder resulting in inattention, hyperactivity, and impulsivity. ADHD is not included in the autism spectrum disorders.">ADHD</cite></a>-like symptoms in people with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>. In <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>, <a class="glossary-term" href="/therapy/ritalin-methylin-methylphenidate-hydrochloride"><cite title=" Ritalin®, Ritalin LA®, Methylin Oral®, or Methylin® are mild central nervous system stimulants that may be prescribed for people with autism to help reduce hyperactivity and repetitive movements. Methylphenidate is indicated for treatment of attention deficit disorder (ADD), attention-deficit/hyperactivity disorder (ADHD), and narcolepsy (falling asleep at the wrong times).">methylphenidate</cite></a> may work better for <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a>, and <a class="glossary-term" href="/therapy/strattera-atomoxetine-hydrochloride"><cite title=" This medication may be prescribed off-label for people with autism to help with hyperactivity, obsessions, and other behavior problems. Strattera® is usually prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). Strattera® works by changing the ways some neurons are turned on and off. One possible serious side effect is increased risk of suicidal thinking and behavior in children, adolescents, and young adults. The risk of this side effect needs to be weighed carefully with the clinical need. Families should be aware of the need for close observation of the child or adolescent taking this medication, and maintain communication with the doctor who prescribed it. ">atomoxetine</cite></a> may work better for attention deficits. Other <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drug therapies</cite></a> may be helpful for <a class="glossary-term" href="/therapy/attention-deficit-hyperactivity-disorder-adhd"><cite title=" ADHD is a neurological disorder resulting in inattention, hyperactivity, and impulsivity. ADHD is not included in the autism spectrum disorders.">ADHD</cite></a>-like symptoms in <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>. <a class="glossary-term" href="/therapy/haldol-haloperidol"><cite title=" Haldol® is an antipsychotic medication that may be prescribed for some people with autism to help control aggression. Haldol is usually used to control tics and vocal utterances in Tourette’s syndrome and to treat schizophrenia. This medication decreases the neurotransmitter dopamine and may have other effects on the nervous system. Scientists do not yet fully understand how Haldol is able to reduce aggression in people with autism. Haldol can cause noticeable side effects including sleepiness and muscle stiffness. ">Haloperidol</cite></a>, <a class="glossary-term" href="/therapy/risperdal-risperidone"><cite title=" 1) aggression, irritability, and severe behavior problems in autistic children 5-16 years old; 2) bipolar mania in individuals 10 years old and up; and 3) schizophrenia in adolescents and adults. Side effects might include weight gain, increased appetite, and sleepy or groggy feelings. Risperdal Consta, an injectable form of risperidone, is usually used to treat schizophrenia in adults. ">risperidone</cite></a>, <a class="glossary-term" href="/therapy/catapres-duraclon-clonidine"><cite title=" Catapres® (generic name clonidine) is usually prescribed to treat high blood pressure by relaxing blood vessels and reducing cardiac output. It has also been used to help alcohol withdrawal, tobacco smoking withdrawal, and diabetic diarrhea. It has been prescribed off-label in the treatment of Attention Deficit Hyperactivity Disorder (ADHD) and Tourette’s Syndrome. Catapres is available as tablets and transdermal patches. Duraclon® is in the form of epidural injections, which are made directly into the nervous system through the spine. It is primarily limited to relief of severe pain, as in cancer patients.">clonidine</cite></a>, <a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">guanfacine</cite></a>, amntadine, and <a class="glossary-term" href="/therapy/revia-vivitrol-naltrexone"><cite title=" This medication may be prescribed for autistic children to help improve ability to socialize and make eye contact, and also to help reduce pain sensitivity, self-injury behaviors, and repetitive behaviors. Revia® is indicated for people who are trying to stop an addiction to alcohol or opioids (e.g., morphine or heroin). This drug is an opioid antagonist, so it binds to opioid receptors and blocks the binding of alcohol or other drugs to the receptors, thus blocking the opiates from having an effect so the person will stop their addiction. Some children with autism have higher than normal levels of beta-endorphins in their nervous system, and naltrexone can lower beta-endorphin levels. An extended release injectable form is also available and is called Vivitrol®. ">naltrexone</cite></a> have been researched. All of these <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drugs</cite></a> have shown improved behaviors in at least one study. However, other studies showed little or no effect of these <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drugs</cite></a> in <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>.</p> </td> </tr> </tbody> </table> </div> attention-deficit hyperactivity disorder (ADHD) autism Catapres - Duraclon (clonidine) Concerta (methylphenidate hydrochloride) drug Haldol (haloperidol) hyperactivity Revia - Vivitrol (naltrexone) Risperdal (risperidone) Ritalin - Methylin (methylphenidate hydrochloride) Strattera (atomoxetine hydrochloride) Tenex - Intuniv (guanfacine) therapy treatment Wed, 14 Oct 2009 18:20:41 +0000 scottie 3591 at http://autism.healingthresholds.com Guanfacine in Children with Autism and/or Intellectual Disabilities http://autism.healingthresholds.com/research/guanfacine-children-autism-andor-intellectual-disabilities <div id="biblio-node"><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.atitle=Guanfacine+in+Children+with+Autism+and%2For+Intellectual+Disabilities&rft.title=Journal+of+Developmental+%26amp%3B+Behavioral+Pediatrics&rft.date=2008&rft.volume=29&rft.issue=4&rft.spage=303&rft.epage=308&rft.aulast=Haden&rft.aufirst=BL"></span><table> <tbody> <tr class="odd"><td class="biblio-row-title biblio-field-title-title">Title</td><td class="biblio-field-contents-title">Guanfacine in Children with Autism and/or Intellectual Disabilities</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-type">Publication Type</td><td class="biblio-field-contents-type">Journal Article</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-authors">Authors</td><td class="biblio-field-contents-authors"><a href="/research-index/author/1647">Haden BL</a>, <a href="/research-index/author/1648">Sahl R</a>, <a href="/research-index/author/1649">Hardan AY</a></td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-secondary-title">Journal Title</td><td class="biblio-field-contents-secondary-title">Journal of Developmental & Behavioral Pediatrics</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-year">Year of Publication</td><td class="biblio-field-contents-year">2008</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-volume">Volume</td><td class="biblio-field-contents-volume">29</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-issue">Issue</td><td class="biblio-field-contents-issue">4</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-pages">Pages</td><td class="biblio-field-contents-pages">303-308</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-url">URL for Abstract</td><td class="biblio-field-contents-url"><a href="http://www.ncbi.nlm.nih.gov/pubmed/18552703?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">http://www.ncbi.nlm.nih.gov/pubmed/18552703?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum</a></td> </tr> <tr class="even"><td valign="top">Full Text</td><td> <p><a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">Guanfacine</cite></a> may be a good <a class="glossary-term" href="/therapy/treatment"><cite title=" Something given to or performed on a person to improve health or behaviors. A treatment can include medical interventions such as giving medications. A treatment can also include non-medical interventions such as acupuncture. A treatment is usually considered something done in limited numbers. A series of treatments is often called therapy.">treatment</cite></a> option for children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> who also have <a class="glossary-term" href="/therapy/attention-deficit-hyperactivity-disorder-adhd"><cite title=" ADHD is a neurological disorder resulting in inattention, hyperactivity, and impulsivity. ADHD is not included in the autism spectrum disorders.">attention deficit/hyperactivity disorder</cite></a> (<a class="glossary-term" href="/therapy/attention-deficit-hyperactivity-disorder-adhd"><cite title=" ADHD is a neurological disorder resulting in inattention, hyperactivity, and impulsivity. ADHD is not included in the autism spectrum disorders.">ADHD</cite></a>).</p> <p>Many times, the <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drugs</cite></a> that are used to treat <a class="glossary-term" href="/therapy/attention-deficit-hyperactivity-disorder-adhd"><cite title=" ADHD is a neurological disorder resulting in inattention, hyperactivity, and impulsivity. ADHD is not included in the autism spectrum disorders.">ADHD</cite></a> do not work as well for children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>. This study was designed to test whether <a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">guanfacine</cite></a> is a good <a class="glossary-term" href="/therapy/treatment"><cite title=" Something given to or performed on a person to improve health or behaviors. A treatment can include medical interventions such as giving medications. A treatment can also include non-medical interventions such as acupuncture. A treatment is usually considered something done in limited numbers. A series of treatments is often called therapy.">treatment</cite></a> for <a class="glossary-term" href="/therapy/attention-deficit-hyperactivity-disorder-adhd"><cite title=" ADHD is a neurological disorder resulting in inattention, hyperactivity, and impulsivity. ADHD is not included in the autism spectrum disorders.">ADHD</cite></a> in children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> and/or other developmental disabilities. This study is the first <a class="glossary-term" href="/therapy/double-blind"><cite title=" Non-biased method of testing the possible effects of a treatment. In a double-blind test, the people who are rating its effectiveness do not know whether the person they are rating has actually received the treatment or placebo. The person they are rating (who took the possible treatment) also does not know.">double-blind</cite></a>, <a class="glossary-term" href="/therapy/placebo"><cite title=" False drug, often consisting of a sugar pill with no active medicine, used for comparison with drugs being tested in a study. Usually the person taking the placebo is not told that they are only taking a sugar pill. ">placebo</cite></a>-<a class="glossary-term" href="/therapy/controlled-study"><cite title=" Experiment using good scientific methods, including double-blind procedures and placebo controls.">controlled study</cite></a> of <a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">guanfacine</cite></a> in children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>. The study combined the children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a> with the children with other developmental disabilities. Three of the 11 children in the study developed sleepiness at the large target dose of 3 mg/day.</p> </td> </tr> </tbody> </table> </div> attention-deficit hyperactivity disorder (ADHD) autism controlled study double-blind drug hyperactivity placebo Tenex - Intuniv (guanfacine) treatment Wed, 29 Oct 2008 14:47:21 +0000 scottie 2875 at http://autism.healingthresholds.com Guanfacine and Guanfacine Extended Release: Treatment for ADHD and Related Disorders http://autism.healingthresholds.com/research/guanfacine-and-guanfacine-extended-release-treatment-adhd-and-related-disorders <div id="biblio-node"><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.atitle=Guanfacine+and+Guanfacine+Extended+Release%3A+Treatment+for+ADHD+and+Related+Disorders&rft.title=CNS+Drug+Reviews&rft.date=2007&rft.volume=13&rft.issue=4&rft.spage=465&rft.epage=474&rft.aulast=Posey&rft.aufirst=DJ"></span><table> <tbody> <tr class="odd"><td class="biblio-row-title biblio-field-title-title">Title</td><td class="biblio-field-contents-title">Guanfacine and Guanfacine Extended Release: Treatment for ADHD and Related Disorders</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-type">Publication Type</td><td class="biblio-field-contents-type">Journal Article</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-authors">Authors</td><td class="biblio-field-contents-authors"><a href="/research-index/author/406">Posey DJ</a>, <a href="/research-index/author/403">McDougle CJ</a></td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-secondary-title">Journal Title</td><td class="biblio-field-contents-secondary-title">CNS Drug Reviews</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-year">Year of Publication</td><td class="biblio-field-contents-year">2007</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-volume">Volume</td><td class="biblio-field-contents-volume">13</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-issue">Issue</td><td class="biblio-field-contents-issue">4</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-pages">Pages</td><td class="biblio-field-contents-pages">465-474</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-url">URL for Abstract</td><td class="biblio-field-contents-url"><a href="http://www.ncbi.nlm.nih.gov/pubmed/18078429?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">http://www.ncbi.nlm.nih.gov/pubmed/18078429?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum</a></td> </tr> <tr class="even"><td valign="top">Full Text</td><td> <p><a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">Guanfacine</cite></a> is a good <a class="glossary-term" href="/therapy/therapy"><cite title=" Intervention intended to help people with autism improve their health and behaviors. Therapy usually implies repeated sessions of treatments or activities. For example, speech therapy involves repeated visits with a trained therapist (or specialist) who works with the child to improve speech.">therapy</cite></a> option for the <a class="glossary-term" href="/therapy/treatment"><cite title=" Something given to or performed on a person to improve health or behaviors. A treatment can include medical interventions such as giving medications. A treatment can also include non-medical interventions such as acupuncture. A treatment is usually considered something done in limited numbers. A series of treatments is often called therapy.">treatment</cite></a> of <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a> in children with <a class="glossary-term" href="/therapy/autism"><cite title=" Neurodevelopmental brain disorder that is characterized by deficits in social interactions and ability to communicate (verbal and nonverbal). People with autism often have atypical patterns of interest or behavior. The term “autism” is commonly used as a general term to include several disorders that fall under the category of autism spectrum disorders (ASD) which are sometimes also called pervasive developmental disorders (PDD).">autism</cite></a>.</p> <p><a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">Guanfacine</cite></a> is one option for treating <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a> (<a class="glossary-term" href="/therapy/attention-deficit-hyperactivity-disorder-adhd"><cite title=" ADHD is a neurological disorder resulting in inattention, hyperactivity, and impulsivity. ADHD is not included in the autism spectrum disorders.">ADHD</cite></a>). The <a class="glossary-term" href="/therapy/food-and-drug-administration-fda"><cite title=" A U.S. government agency that is responsible for assuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation’s food supply, cosmetics, and products that emit radiation; for example, prescription drugs are regulated by the FDA. The web address is www.fda.gov.">FDA</cite></a> will likely soon approve an extended release form of <a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">guanfacine</cite></a>. <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">Hyperactivity</cite></a> can be a problem in about half of children with <a class="glossary-term" href="/therapy/pervasive-developmental-disorder-pdd"><cite title=" Defined as a broad category of disorders in which there is a delay in the development of basic functions including communication and social interaction. PDD includes autism spectrum disorders (autism disorder, childhood disintegration disorder, Rett syndrome, Asperger’s syndrome, and PDD-not otherwise specified or PDD-NOS).">pervasive developmental disorder (PDD)</cite></a>. This paper includes a review of the use of <a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">guanfacine</cite></a> to treat <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a> in children with <a class="glossary-term" href="/therapy/pervasive-developmental-disorder-pdd"><cite title=" Defined as a broad category of disorders in which there is a delay in the development of basic functions including communication and social interaction. PDD includes autism spectrum disorders (autism disorder, childhood disintegration disorder, Rett syndrome, Asperger’s syndrome, and PDD-not otherwise specified or PDD-NOS).">PDD</cite></a>. One study found that <a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">guanfacine</cite></a> worked for about 25% of children with <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a> and <a class="glossary-term" href="/therapy/pervasive-developmental-disorder-pdd"><cite title=" Defined as a broad category of disorders in which there is a delay in the development of basic functions including communication and social interaction. PDD includes autism spectrum disorders (autism disorder, childhood disintegration disorder, Rett syndrome, Asperger’s syndrome, and PDD-not otherwise specified or PDD-NOS).">PDD</cite></a>. Another study found that <a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">guanfacine</cite></a> worked for about half of children with <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a> and <a class="glossary-term" href="/therapy/pervasive-developmental-disorder-pdd"><cite title=" Defined as a broad category of disorders in which there is a delay in the development of basic functions including communication and social interaction. PDD includes autism spectrum disorders (autism disorder, childhood disintegration disorder, Rett syndrome, Asperger’s syndrome, and PDD-not otherwise specified or PDD-NOS).">PDD</cite></a>.</p> </td> </tr> </tbody> </table> </div> attention-deficit hyperactivity disorder (ADHD) autism drug hyperactivity pervasive developmental disorder (PDD) Tenex - Intuniv (guanfacine) therapy treatment Mon, 05 May 2008 13:40:23 +0000 scottie 2494 at http://autism.healingthresholds.com A Prospective Open Trial of Guanfacine in Children with Pervasive Developmental Disorders http://autism.healingthresholds.com/research/prospective-open-trial-guanfacine-children-pervasive-developmental-disorders <div id="biblio-node"><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.atitle=A+Prospective+Open+Trial+of+Guanfacine+in+Children+with+Pervasive+Developmental+Disorders&rft.title=Journal+of+Child+and+Adolescent+Psychopharmacology&rft.date=2006&rft.volume=16&rft.issue=5&rft.spage=589&rft.epage=598&rft.aulast=Scahill&rft.auinit=L"></span><table> <tbody> <tr class="odd"><td class="biblio-row-title biblio-field-title-title">Title</td><td class="biblio-field-contents-title">A Prospective Open Trial of Guanfacine in Children with Pervasive Developmental Disorders</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-type">Publication Type</td><td class="biblio-field-contents-type">Journal Article</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-authors">Authors</td><td class="biblio-field-contents-authors"><a href="/research-index/author/498">Scahill L</a>, <a href="/research-index/author/439">Aman MG</a>, <a href="/research-index/author/403">McDougle CJ</a>, <a href="/research-index/author/499">McCracken JT</a>, <a href="/research-index/author/500">Tierney E</a>, <a href="/research-index/author/501">Dziura J</a>, <a href="/research-index/author/243">Arnold LE</a>, <a href="/research-index/author/502">Posey D</a>, <a href="/research-index/author/503">Young C</a>, <a href="/research-index/author/504">Shah B</a>, <a href="/research-index/author/505">Ghuman J</a>, <a href="/research-index/author/506">Ritz L</a>, <a href="/research-index/author/507">Vitiello B</a></td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-secondary-title">Journal Title</td><td class="biblio-field-contents-secondary-title">Journal of Child and Adolescent Psychopharmacology</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-year">Year of Publication</td><td class="biblio-field-contents-year">2006</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-volume">Volume</td><td class="biblio-field-contents-volume">16</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-issue">Issue</td><td class="biblio-field-contents-issue">5</td> </tr> <tr class="even"><td class="biblio-row-title biblio-field-title-pages">Pages</td><td class="biblio-field-contents-pages">589-598</td> </tr> <tr class="odd"><td class="biblio-row-title biblio-field-title-url">URL for Abstract</td><td class="biblio-field-contents-url"><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17069547&query_hl=2&itool=pubmed_docsum">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17069547&query_hl=2&itool=pubmed_docsum</a></td> </tr> <tr class="even"><td valign="top">Full Text</td><td> <p><a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">Guanfacine</cite></a> may help to treat <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a> in children with <a class="glossary-term" href="/therapy/pervasive-developmental-disorder-pdd"><cite title=" Defined as a broad category of disorders in which there is a delay in the development of basic functions including communication and social interaction. PDD includes autism spectrum disorders (autism disorder, childhood disintegration disorder, Rett syndrome, Asperger’s syndrome, and PDD-not otherwise specified or PDD-NOS).">pervasive developmental disorder (PDD)</cite></a>.</p> <p>This article describes a <a class="glossary-term" href="/therapy/prospective-study"><cite title=" Type of scientific study designed to plan in advance what will be measured, and then measure it during the study. A prospective study is different from a retrospective study, which is based on data collected by remembering or measuring things that have already happened.">prospective study</cite></a>. This means that the children were entered into the study and then given <a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">guanfacine</cite></a> in order to treat <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a>. The study found that children had 39% less <a class="glossary-term" href="/therapy/hyperactivity"><cite title=" A physical state of abnormal activity. Some research has shown that food additives may cause hyperactivity in children.">hyperactivity</cite></a> and impulsive behavior when they were given the <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drug</cite></a>. This improvement was seen by <a class="glossary-term" href="/therapy/parent"><cite title=" A parent is a person, usually a mother or father, who takes care of a child. Parents can be biological or adoptive. Parents teach social, moral, and communication skills to their children. They are responsible for their well-being and education.">parents</cite></a> and by teachers. <a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">Guanfacine</cite></a> also seemed to help with irritability, explosive behavior, repetitive movements (stereotypies), and <a class="glossary-term" href="/therapy/joint-attention"><cite title=" Part of a social interaction when two people connect and pay attention to each other or to the same object or event.">social interaction</cite></a>. The authors suggest that <a class="glossary-term" href="/therapy/tenex-intuniv-guanfacine"><cite title=" Tenex® or Intuniv® (extended release form) stimulates certain receptors in the brain and nervous system. Guanfacine is indicated for lowering blood pressure and improving attention in attention-deficit hyperactivity disorder (ADHD). Guanfacine may also be prescribed off-label for sleep disorders, post-traumatic stress disorder, anti-social behaviors, oppositional disorder, and Tourette’s disorder. ">guanfacine</cite></a> be used in children who do not respond to the <a class="glossary-term" href="/therapy/drug"><cite title=" Chemical or medication that leads to changes in the body, usually with the goal of improving health. In some cases drugs can be abused, as in illegal drugs. Drugs include medications prescribed by medical professionals, as well as over-the-counter (OTC) medications. ">drug</cite></a> <a class="glossary-term" href="/therapy/ritalin-methylin-methylphenidate-hydrochloride"><cite title=" Ritalin®, Ritalin LA®, Methylin Oral®, or Methylin® are mild central nervous system stimulants that may be prescribed for people with autism to help reduce hyperactivity and repetitive movements. Methylphenidate is indicated for treatment of attention deficit disorder (ADD), attention-deficit/hyperactivity disorder (ADHD), and narcolepsy (falling asleep at the wrong times).">methylphenidate</cite></a>.</p> </td> </tr> </tbody> </table> </div> Concerta (methylphenidate hydrochloride) drug hyperactivity joint attention parent pervasive developmental disorder (PDD) prospective study Ritalin - Methylin (methylphenidate hydrochloride) Tenex - Intuniv (guanfacine) Thu, 18 Jan 2007 23:08:05 +0000 scottie 1103 at http://autism.healingthresholds.com