Research summaries for autism therapy: Thorazine (chlorpromazine)

definition of Thorazine (chlorpromazine): Thorazine® Spansule® is the name for the sustained-release form. Chlorpromazine is available in tablet or injection form, and as suppositories. In children 1-12 years old, Thorazine® may be prescribed for the treatment of severe behavioral problems such as combativeness and/or explosive hyperexcitable behavior. It is also prescribed for short-term treatment of hyperactive children who show excessive motor activity and conduct disorders that may include impulsivity, difficulty sustaining attention, aggressiveness, mood swings, and poor frustration tolerance. Thorazine® is approved for the treatment of a number of other different conditions, including schizophrenia, severe nausea and vomiting, manic type of manic-depressive disorder.

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Some children with autism have many different medical problems and it is important for the treating doctor to constantly be watching and changing the drugs and their dosages as symptoms change.... Children with PDD and seizures, for example often need drug therapy to help the seizures and the behavior problems. There are two older drugs (chlorpromazine and haloperidol) in addition to risperidone that are sometimes given as a treatment to children with behavior problems. Drugs can sometimes work together and sometimes work against each other; therefore, the authors suggest that changes in drugs and drug dosage be made slowly.... Read more...

Aripiprazole treatment may help to decrease violence and increase physical activity in people with autism.... Before starting the study, he was given risperidone (3 mg twice daily) and chlorpromazine (100 mg three times a day) and had gained 150 pounds in 2 years. During the study he was given aripiprazole (15 mg/day) and gradually taken off of risperidone.... Read more...

Antipsychotics have not yet been proven to be effective in children with autism. Antipsychotics such as chlorpromazine, thioridazine, haloperidol, and risperidone are occasionally used to treat pervasive developmental disorders (PDD) such as autism. The authors reviewed the scientific literature to determine whether these drugs are safe and effective for children with autism. In general, they found that anti-psychotics were ineffective in treating autism.... Read more...


Synonyms for Thorazine (chlorpromazine) include: chlorpromazine, Thorazine, Thorazine Spansule, Thorazine®, Thorazine® Spansule®
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