Autism Therapy: vitamin D (calciferol)

definition of vitamin D (calciferol): Group of fat-soluble compounds that play an important role in calcium absorption and in immune system functions. Vitamin D is likely to be important for many other functions in the body as well. Vitamin D is found in foods including enriched milk and mushrooms. The body can make vitamin D during exposure to sunlight. Scientists are studying the importance of vitamin D in autism.

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Alternative Therapies in Health and Medicine, by Morris, CR, and Agin MC, published in 2009, summarized Sep 4, 2009

Combined vitamin E and omega 3 therapy may help a type of verbal apraxia (speech problems) that may be caused by food allergies and nutritional problems, and could affect children with autism.

Children with verbal apraxia have trouble saying words and may have severe speech problems. Many scientists have thought that verbal apraxia is a brain disorder. This study suggests that verbal apraxia may be a result of nutritional problems. This study tested 187 children with verbal apraxia. Many of the children also had autism. All children took 400-3,000 International Units (IU) of vitamin E daily. They also took 1-3 grams of polyunsaturated fats (including omega 3 fatty acids) per day. Almost all of the families reported that the children who received vitamin E and omega 3 therapy had better speech, imitation, coordination, and eye contact. The authors also described blood test results for 26 of the children. They reported low carnitine levels, high anti-gluten antibodies, low vitamin D levels, fat absorption problems, and other results. The authors described how nutrition and metabolism might be different in some children with autism. The authors said that two major problems with this study were that they asked parents to give their own opinion of whether or not the children were getting better, and they did not use placebo controls. Even so, they said the results are very promising.


Alternative Medicine Review, by Cannell, JJ, and Hollis BW, published in 2008, summarized May 12, 2008

Vitamin D therapy (by oral vitamin or sun) may help the symptoms of autism as well as muscle weakness and common winter colds.

This review article describes the use of vitamin D therapy. The authors believe that people with autism should have vitamin D levels between 55 and 70 ng/mL year round. This is about twice the level commonly found during the winter in people living in the United States. They wonder whether one of the causes of the increased rate of autism may be from lack of vitamin D because people (pregnant women and children) avoid the sun. They note that vitamin D acts on most tissues of the body and may be able to prevent autism. Treatment with vitamin D needs to be followed by a doctor because it is hard to know whether or not a given vitamin dose taken by mouth will cause a certain blood level.


Medical Hypotheses, by Cannell, JJ, published in 2008, summarized Apr 16, 2008

Playing in the sun (without sunscreen) may help autism.

This paper describes the idea that autism could be caused by lack of vitamin D. The author notes that the number of autism cases have gone up along with the advice to use sunscreen. The author believes that the link between vitamin D and autism should be tested in a large randomized controlled trial. He wonders if mothers who avoid the sun are more likely to give birth to children with autism. Vitamin D supplements may not be a good intervention since vitamin D does not absorb easily from the gut.


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Please comment on this autism topic.

This is in response to Dr. Jay L. Hoecker, an emeritus consultant in Mayo Clinic’s Department of Pediatric and Adolescent Medicine, suggests that parents of children with autism should be careful when starting their child on a new diet.

What terrible advice.  It is not hard to do a Gluten Free Casein Free Diet and in fact is healthier than most diets people have their children on. 

It is meat, vegetables, fruits, and avoiding wheat based flours, but this doesn't mean they don't eat "grains" .  It is about cooking from scratch.  It means no preservatives, or colored dyes.

Calcium and Vitamin D can be achieved from Almond Milk or Rice Milk.

The added comment that "Temple Grandin's Mother didn't put her on this diet is ridiculous.  I know first hand that when my daughter has "gluten" she regresses in her behaviors, her ability to concentrate and her ability to talk.

It sunds like Dr. Jay is just another doctor that would rather pump kids with drugs that go the natural healing route.  Simply appalling!


 

Can nutrition help verbal skills in children with autism? A study reported the August 2009 issue of Alternative Therapies says yes, for some children. Combined vitamin E and omega 3 therapy may help a type of verbal apraxia (a type of speech problem) that may be linked to food allergies and nutritional problems.

 Children with verbal apraxia have trouble pronouncing words and may have severe speech problems. Many scientists have thought that verbal apraxia is a brain disorder. This study suggests that verbal apraxia may also be related to metabolism differences and nutritional problems.

 Metabolism is the process of making energy from food. Metabolism is a complex system of enzymes, proteins, fats, and carbohydrates that work together to digest food and turn it into energy that the body can use. People likely have a wide range of metabolic differences. Some of those differences can be quite large for some individuals. In this study, they suggest that some children with autism may have metabolism differences that affect how they process foods, and how their brain works.

 What did the study show? This study tested 187 children with verbal apraxia, and many of them also had autism. All of the children took 400-3,000 International Units of vitamin E daily. They also took 1-3 grams of polyunsaturated fats (including omega 3 fatty acids) per day.

 Almost all of the families (97%) reported improvements in speech, imitation, coordination, eye contact, and other skills with vitamin E and omega-3 therapy. There were few side effects reported during the length of the study.

 The authors also described blood test results for nutritional information about 26 of the children. They reported low carnitine levels, high anti-gluten antibodies (suggesting a gluten allergy), low vitamin D levels, and fat absorption problems in most of the children they tested. They described how nutrition and metabolism might be different in some children with autism.

 What do these results mean for children with verbal apraxia and autism? The results are exciting because 97% of the children showed improvements, and there were few side effects. Sounds perfect, doesn’t it? But it’s not quite as perfect as it sounds.

 There are some major limitations of this study. First of all, the researchers asked parents to give their subjective opinion of improvements. The parents knew they were in a study. Although they were given specific improvements to look for, there is a possibility of bias in favor of reporting a good result.

 Secondly, they did not use placebo controls. All of the parents and children knew they were getting the supplements. There is the possibility of the “placebo effect” which is when people taking placebo (“sugar pills”) report feeling better or actually show improvements. Many think it is the power of the mind/body connection that somehow influences how they feel or even how their body physically responds. There is scientific evidence for brain connections to the immune and endocrine systems to support these observations. It is possible that, in this study, the children and/or parents were hopeful that the supplements would work, and that influenced the outcome. There was a placebo effect observed in a recent study of citalopram and autism in children.

 Third, the supplements may be helpful for only a subset of children with verbal apraxia. The researchers chose children with verbal apraxia who also had metabolism differences….

 What is the bottom line for omega-3 and vitamin E from this study? In spite of the shortcomings of this study, the results are very promising. Children with verbal apraxia may benefit from vitamin E and omega-3 supplements, which may get their metabolism on a better track. And researchers will continue to explore the nutrition/metabolism link with brain function. Good nutrition is likely to be important for many brain functions, not just verbal apraxia.



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  • Synonyms for vitamin D (calciferol) include: calciferol, cholecalciferol, ergocalciferol, vitamin D
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